CAMSAP3 explained

Calmodulin-regulated spectrin-associated protein family member 3 (CAMSAP3) is a human protein encoded by the gene CAMSAP3. The protein is commonly referred to as Nezha.

Function

CAMSAP3 acts as a minus-end anchor of microtubules, and binds to them through its CKK domain.^[1]

In epithelial cells, it anchors microtubules to the apical cortex, causing them to grow in an apical-to-basal direction.^[2] This gives the epithelial cells their rectangular shape.

In early mouse embryogenesis, the interphase bridge linking sister cells is enriched with CAMSAP3.^[3]

See also

• CAMSAP1
• CAMSAP2

Notes and References

1. Baines . A. J. . Bignone . P. A. . King . M. D.A. . Maggs . A. M. . Bennett . P. M. . Pinder . J. C. . Phillips . G. W. . 2009-09-01 . The CKK Domain (DUF1781) Binds Microtubules and Defines the CAMSAP/ssp4 Family of Animal Proteins . Molecular Biology and Evolution . en . 26 . 9 . 2005–2014 . 10.1093/molbev/msp115 . 19508979 . 0737-4038 . free . 2022-09-29 . 2022-06-15 . https://web.archive.org/web/20220615164311/https://academic.oup.com/mbe/article-lookup/doi/10.1093/molbev/msp115 . live .
2. Toya M, Kobayashi S, Kawasaki M, Shioi G, Kaneko M, Ishiuchi T, Misaki K, Meng W, Takeichi M . 6 . CAMSAP3 orients the apical-to-basal polarity of microtubule arrays in epithelial cells . Proceedings of the National Academy of Sciences of the United States of America . 113 . 2 . 332–337 . January 2016 . 26715742 . 4720291 . 10.1073/pnas.1520638113 . 2016PNAS..113..332T . free .
3. Zenker J, White MD, Templin RM, Parton RG, Thorn-Seshold O, Bissiere S, Plachta N . A microtubule-organizing center directing intracellular transport in the early mouse embryo . Science . 357 . 6354 . 925–928 . September 2017 . 28860385 . 10.1126/science.aam9335 . 2017Sci...357..925Z . 206658036 . free .