CAMSAP1 explained

Calmodulin-regulated spectrin-associated protein 1 (CAMSAP1) is a human protein encoded by the gene CAMSAP1. Like other CAMSAP-family proteins, it is a microtubule minus-end anchor, and binds microtubules through its CKK domain.^[1]

Clinical significance

CAMSAP1 is vital for neuron polarisation, and so mice that lack CAMSAP1 die of epileptic seizures.^[2]

See also

• CAMSAP2
• CAMSAP3

Notes and References

1. Baines . A. J. . Bignone . P. A. . King . M. D.A. . Maggs . A. M. . Bennett . P. M. . Pinder . J. C. . Phillips . G. W. . 2009-09-01 . The CKK Domain (DUF1781) Binds Microtubules and Defines the CAMSAP/ssp4 Family of Animal Proteins . Molecular Biology and Evolution . en . 26 . 9 . 2005–2014 . 10.1093/molbev/msp115 . 19508979 . 0737-4038. free .
2. Zhou Z, Xu H, Li Y, Yang M, Zhang R, Shiraishi A, Kiyonari H, Liang X, Huang X, Wang Y, Xie Q, Liu S, Chen R, Bao L, Guo W, Wang Y, Meng W . 6 . CAMSAP1 breaks the homeostatic microtubule network to instruct neuronal polarity . Proceedings of the National Academy of Sciences of the United States of America . 117 . 36 . 22193–22203 . September 2020 . 32839317 . 7486724 . 10.1073/pnas.1913177117 . 2020PNAS..11722193Z . free .