CAMKK1 explained

Calcium/calmodulin-dependent protein kinase kinase 1 is an enzyme that in humans is encoded by the CAMKK1 gene.^{[1] [2]}

The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase (CAMK) subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene.

Further reading

• Selbert MA, Anderson KA, Huang QH . Phosphorylation and activation of Ca(2+)-calmodulin-dependent protein kinase IV by Ca(2+)-calmodulin-dependent protein kinase Ia kinase. Phosphorylation of threonine 196 is essential for activation . J. Biol. Chem. . 270 . 29 . 17616–21 . 1995 . 7615569 . 10.1074/jbc.270.29.17616. etal. free .
• Tokumitsu H, Enslen H, Soderling TR . Characterization of a Ca2+/calmodulin-dependent protein kinase cascade. Molecular cloning and expression of calcium/calmodulin-dependent protein kinase kinase . J. Biol. Chem. . 270 . 33 . 19320–4 . 1995 . 7642608 . 10.1074/jbc.270.33.19320. free .
• Tokumitsu H, Soderling TR . Requirements for calcium and calmodulin in the calmodulin kinase activation cascade . J. Biol. Chem. . 271 . 10 . 5617–22 . 1996 . 8621423 . 10.1074/jbc.271.10.5617 . free .
• Matsushita M, Nairn AC . Characterization of the mechanism of regulation of Ca2+/ calmodulin-dependent protein kinase I by calmodulin and by Ca2+/calmodulin-dependent protein kinase kinase . J. Biol. Chem. . 273 . 34 . 21473–81 . 1998 . 9705275 . 10.1074/jbc.273.34.21473 . free .
• Matsushita M, Nairn AC . Inhibition of the Ca2+/calmodulin-dependent protein kinase I cascade by cAMP-dependent protein kinase . J. Biol. Chem. . 274 . 15 . 10086–93 . 1999 . 10187789 . 10.1074/jbc.274.15.10086 . free .
• Lawson ND, Zain M, Zibello T . Modulation of a calcium/calmodulin-dependent protein kinase cascade by retinoic acid during neutrophil maturation . Exp. Hematol. . 27 . 11 . 1682–90 . 1999 . 10560916 . 10.1016/S0301-472X(99)00108-3 . etal. free .
• Okuno S, Kitani T, Matsuzaki H . Studies on the phosphorylation of protein kinase B by Ca(2+)/calmodulin-dependent protein kinases . J. Biochem. . 127 . 6 . 965–70 . 2000 . 10833263 . 10.1093/oxfordjournals.jbchem.a022712. etal.
• Okuno S, Kitani T, Fujisawa H . Regulation of Ca(2+)/calmodulin-dependent protein kinase kinase alpha by cAMP-dependent protein kinase: I. Biochemical analysis . J. Biochem. . 130 . 4 . 503–13 . 2002 . 11574070 . 10.1093/oxfordjournals.jbchem.a003013.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Imai S, Okayama N, Shimizu M, Itoh M . Increased intracellular calcium activates serum and glucocorticoid-inducible kinase 1 (SGK1) through a calmodulin-calcium calmodulin dependent kinase kinase pathway in Chinese hamster ovary cells . Life Sci. . 72 . 20 . 2199–209 . 2003 . 12628440 . 10.1016/S0024-3205(03)00092-4 .
• Ishikawa Y, Tokumitsu H, Inuzuka H . Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells . FEBS Lett. . 550 . 1–3 . 57–63 . 2003 . 12935886 . 10.1016/S0014-5793(03)00817-2 . 22116744 . etal. free .
• Jin J, Smith FD, Stark C . Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization . Curr. Biol. . 14 . 16 . 1436–50 . 2004 . 15324660 . 10.1016/j.cub.2004.07.051 . 2371325 . etal. free . 2004CBio...14.1436J .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.

Notes and References

1. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs . Genome Res . 11 . 3 . 422–35 . Mar 2001 . 11230166 . 311072 . 10.1101/gr.GR1547R .
2. Web site: Entrez Gene: CAMKK1 calcium/calmodulin-dependent protein kinase kinase 1, alpha.