CAMK1 explained

Calcium/calmodulin-dependent protein kinase type 1 is an enzyme that in humans is encoded by the CAMK1 gene.^[1]

Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase.^[2]

Further reading

• Bredt DS, Ferris CD, Snyder SH . Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites . J. Biol. Chem. . 267 . 16 . 10976–81 . 1992 . 10.1016/S0021-9258(19)49862-1 . 1375933 . free .
• Yokokura H, Picciotto MR, Nairn AC, Hidaka H . The regulatory region of calcium/calmodulin-dependent protein kinase I contains closely associated autoinhibitory and calmodulin-binding domains . J. Biol. Chem. . 270 . 40 . 23851–9 . 1995 . 7559563 . 10.1074/jbc.270.40.23851 . free .
• Liu F, Thompson MA, Wagner S . Activating transcription factor-1 can mediate Ca(2+)- and cAMP-inducible transcriptional activation . J. Biol. Chem. . 268 . 9 . 6714–20 . 1993 . 10.1016/S0021-9258(18)53308-1 . 8384217 . etal. free .
• Chin D, Winkler KE, Means AR . Characterization of substrate phosphorylation and use of calmodulin mutants to address implications from the enzyme crystal structure of calmodulin-dependent protein kinase I . J. Biol. Chem. . 272 . 50 . 31235–40 . 1998 . 9395448 . 10.1074/jbc.272.50.31235 . free .
• Hsu LS, Tsou AP, Chi CW . Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase . J. Biomed. Sci. . 5 . 2 . 141–9 . 1998 . 9662074 . 10.1007/bf02258368. etal.
• Matsushita M, Nairn AC . Characterization of the mechanism of regulation of Ca2+/ calmodulin-dependent protein kinase I by calmodulin and by Ca2+/calmodulin-dependent protein kinase kinase . J. Biol. Chem. . 273 . 34 . 21473–81 . 1998 . 9705275 . 10.1074/jbc.273.34.21473 . free .
• Anderson KA, Means RL, Huang QH . Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta . J. Biol. Chem. . 273 . 48 . 31880–9 . 1998 . 9822657 . 10.1074/jbc.273.48.31880 . etal. free .
• Matsushita M, Nairn AC . Inhibition of the Ca2+/calmodulin-dependent protein kinase I cascade by cAMP-dependent protein kinase . J. Biol. Chem. . 274 . 15 . 10086–93 . 1999 . 10187789 . 10.1074/jbc.274.15.10086 . free .
• Hayashi Y, Nishio M, Naito Y . Regulation of neuronal nitric-oxide synthase by calmodulin kinases . J. Biol. Chem. . 274 . 29 . 20597–602 . 1999 . 10400690 . 10.1074/jbc.274.29.20597 . etal. free .
• Hosaka M, Hammer RE, Südhof TC . A phospho-switch controls the dynamic association of synapsins with synaptic vesicles . Neuron . 24 . 2 . 377–87 . 1999 . 10571231 . 10.1016/S0896-6273(00)80851-X . 14103027 . free .
• Komeima K, Hayashi Y, Naito Y, Watanabe Y . Inhibition of neuronal nitric-oxide synthase by calcium/ calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG108-15 neuronal cells . J. Biol. Chem. . 275 . 36 . 28139–43 . 2000 . 10874031 . 10.1074/jbc.M003198200 . free .
• McKinsey TA, Zhang CL, Lu J, Olson EN . Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation . Nature . 408 . 6808 . 106–11 . 2000 . 11081517 . 10.1038/35040593 . 4459600 . 2000Natur.408..106M .
• McKinsey TA, Zhang CL, Olson EN . Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5 . Proc. Natl. Acad. Sci. U.S.A. . 97 . 26 . 14400–5 . 2001 . 11114197 . 10.1073/pnas.260501497 . 18930 . 2000PNAS...9714400M . free .
• Hsu LS, Chen GD, Lee LS . Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity . J. Biol. Chem. . 276 . 33 . 31113–23 . 2001 . 11395482 . 10.1074/jbc.M011720200 . etal. free .
• Condon JC, Pezzi V, Drummond BM . Calmodulin-dependent kinase I regulates adrenal cell expression of aldosterone synthase . Endocrinology . 143 . 9 . 3651–7 . 2002 . 12193581 . 10.1210/en.2001-211359 . etal. free .
• Sakurada K, Kato H, Nagumo H . Synapsin I is phosphorylated at Ser603 by p21-activated kinases (PAKs) in vitro and in PC12 cells stimulated with bradykinin . J. Biol. Chem. . 277 . 47 . 45473–9 . 2003 . 12237306 . 10.1074/jbc.M206673200 . etal. free .
• Clapperton JA, Martin SR, Smerdon SJ . Structure of the complex of calmodulin with the target sequence of calmodulin-dependent protein kinase I: studies of the kinase activation mechanism . Biochemistry . 41 . 50 . 14669–79 . 2003 . 12475216 . 10.1021/bi026660t . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Izmailova E, Bertley FM, Huang Q . HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages . Nat. Med. . 9 . 2 . 191–7 . 2003 . 12539042 . 10.1038/nm822 . 26145639 . etal.

Notes and References

1. Haribabu B, Hook SS, Selbert MA, Goldstein EG, Tomhave ED, Edelman AM, Snyderman R, Means AR . Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase . EMBO J . 14 . 15 . 3679–86 . Sep 1995 . 7641687 . 394442 . 10.1002/j.1460-2075.1995.tb00037.x.
2. Web site: Entrez Gene: CAMK1 calcium/calmodulin-dependent protein kinase I.