CAMK2B explained

Calcium/calmodulin-dependent protein kinase type II beta chain is an enzyme that in humans is encoded by the CAMK2B gene.

Function

The enzyme belongs to the serine/threonine protein kinase family and to the Ca²⁺/calmodulin-dependent protein kinase subfamily. Calcium signalling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Eight transcript variants encoding eight distinct isoforms have been identified for this gene.^[1]

Interactions

CAMK2B has been shown to interact with Actinin alpha 4.^[2]

Further reading

• Yamamoto H . [Molecular mechanisms of the intracellular localizations of Ca2+/calmodulin-dependent protein kinase II isoforms, and their physiological functions] . Tanpakushitsu Kakusan Koso . 47 . 3 . 241–7 . 2002 . 11889801 .
• Thiel G, Czernik AJ, Gorelick F, Nairn AC, Greengard P . Ca2+/calmodulin-dependent protein kinase II: identification of threonine-286 as the autophosphorylation site in the alpha subunit associated with the generation of Ca2+-independent activity . Proc. Natl. Acad. Sci. U.S.A. . 85 . 17 . 6337–41 . 1988 . 2842767 . 281965 . 10.1073/pnas.85.17.6337 . 1988PNAS...85.6337T . free .
• Schworer CM, Colbran RJ, Keefer JR, Soderling TR . Ca2+/calmodulin-dependent protein kinase II. Identification of a regulatory autophosphorylation site adjacent to the inhibitory and calmodulin-binding domains . J. Biol. Chem. . 263 . 27 . 13486–9 . 1988 . 10.1016/S0021-9258(18)68264-X . 3417668 . free .
• Penadés JR, Bernal D, Revert F, Johansson C, Fresquet VJ, Cervera J, Wieslander J, Quinones S, Saus J . Characterization and expression of multiple alternatively spliced transcripts of the Goodpasture antigen gene region. Goodpasture antibodies recognize recombinant proteins representing the autoantigen and one of its alternative forms . Eur. J. Biochem. . 229 . 3 . 754–60 . 1995 . 7758473 . 10.1111/j.1432-1033.1995.tb20524.x .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Omkumar RV, Kiely MJ, Rosenstein AJ, Min KT, Kennedy MB . Identification of a phosphorylation site for calcium/calmodulindependent protein kinase II in the NR2B subunit of the N-methyl-D-aspartate receptor . J. Biol. Chem. . 271 . 49 . 31670–8 . 1997 . 8940188 . 10.1074/jbc.271.49.31670 . free .
• Tombes RM, Krystal GW . Identification of novel human tumor cell-specific CaMK-II variants . Biochim. Biophys. Acta . 1355 . 3 . 281–92 . 1997 . 9060999 . 10.1016/S0167-4889(96)00141-3 .
• Moyers JS, Bilan PJ, Zhu J, Kahn CR . Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II . J. Biol. Chem. . 272 . 18 . 11832–9 . 1997 . 9115241 . 10.1074/jbc.272.18.11832 . free .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Chang BH, Mukherji S, Soderling TR . Characterization of a calmodulin kinase II inhibitor protein in brain . Proc. Natl. Acad. Sci. U.S.A. . 95 . 18 . 10890–5 . 1998 . 9724800 . 27991 . 10.1073/pnas.95.18.10890 . 1998PNAS...9510890C . free .
• Rochlitz H, Voigt A, Lankat-Buttgereit B, Göke B, Heimberg H, Nauck MA, Schiemann U, Schatz H, Pfeiffer AF . Cloning and quantitative determination of the human Ca2+/calmodulin-dependent protein kinase II (CaMK II) isoforms in human beta cells . Diabetologia . 43 . 4 . 465–73 . 2000 . 10819240 . 10.1007/s001250051330 . free .
• Wang P, Wu YL, Zhou TH, Sun Y, Pei G . Identification of alternative splicing variants of the beta subunit of human Ca(2+)/calmodulin-dependent protein kinase II with different activities . FEBS Lett. . 475 . 2 . 107–10 . 2000 . 10858498 . 10.1016/S0014-5793(00)01634-3 . 39732332 . free .
• Novak G, Seeman P, Tallerico T . Schizophrenia: elevated mRNA for calcium-calmodulin-dependent protein kinase IIbeta in frontal cortex . Brain Res. Mol. Brain Res. . 82 . 1–2 . 95–100 . 2001 . 11042361 . 10.1016/S0169-328X(00)00188-1 .
• Hartley JL, Temple GF, Brasch MA . DNA Cloning Using In Vitro Site-Specific Recombination . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 310948 . 10.1101/gr.143000 .
• Walikonis RS, Oguni A, Khorosheva EM, Jeng CJ, Asuncion FJ, Kennedy MB . Densin-180 forms a ternary complex with the (alpha)-subunit of Ca2+/calmodulin-dependent protein kinase II and (alpha)-actinin . J. Neurosci. . 21 . 2 . 423–33 . 2001 . 11160423 . 10.1523/JNEUROSCI.21-02-00423.2001. 6763799 .
• Liao GY, Wagner DA, Hsu MH, Leonard JP . Evidence for direct protein kinase-C mediated modulation of N-methyl-D-aspartate receptor current . Mol. Pharmacol. . 59 . 5 . 960–4 . 2001 . 11306676 . 10.1124/mol.59.5.960.
• Yue C, Sanborn BM . KN-93 inhibition of G protein signaling is independent of the ability of Ca2+/calmodulin-dependent protein kinase II to phosphorylate phospholipase Cbeta3 on 537-Ser . Mol. Cell. Endocrinol. . 175 . 1–2 . 149–56 . 2001 . 11325525 . 10.1016/S0303-7207(01)00383-5 . 338776 .
• Schell MJ, Erneux C, Irvine RF . Inositol 1,4,5-trisphosphate 3-kinase A associates with F-actin and dendritic spines via its N terminus . J. Biol. Chem. . 276 . 40 . 37537–46 . 2001 . 11468283 . 10.1074/jbc.M104101200 . free .
• Li G, Laabich A, Liu LO, Xue J, Cooper NG . Molecular cloning and sequence analyses of calcium/calmodulin-dependent protein kinase II from fetal and adult human brain. Sequence analyses of human brain calcium/calmodulin-dependent protein kinase II . Mol. Biol. Rep. . 28 . 1 . 35–41 . 2002 . 11710563 . 10.1023/A:1011951814898 . 22670733 .
• Poggi A, Carosio R, Spaggiari GM, Fortis C, Tambussi G, Dell'Antonio G, Dal Cin E, Rubartelli A, Zocchi MR . NK cell activation by dendritic cells is dependent on LFA-1-mediated induction of calcium-calmodulin kinase II: inhibition by HIV-1 Tat C-terminal domain . J. Immunol. . 168 . 1 . 95–101 . 2002 . 11751951 . 10.4049/jimmunol.168.1.95 . free .

Notes and References

1. Web site: Entrez Gene: CAMK2B calcium/calmodulin-dependent protein kinase (CaM kinase) II beta.
2. Walikonis RS, Oguni A, Khorosheva EM, Jeng CJ, Asuncion FJ, Kennedy MB. Mary B. Kennedy . Densin-180 forms a ternary complex with the (alpha)-subunit of Ca2+/calmodulin-dependent protein kinase II and (alpha)-actinin . J. Neurosci. . 21 . 2 . 423–33 . Jan 2001 . 11160423 . 6763799 . 10.1523/JNEUROSCI.21-02-00423.2001 .