CALY explained

Neuron-specific vesicular protein calcyon is a protein that in humans is encoded by the CALY gene.^{[1] [2]} Its alternative name is Calcyon.

Function

The protein encoded by this gene is a type II single transmembrane protein. It is required for maximal stimulated calcium release after stimulation of purinergic or muscarinic but not beta-adrenergic receptors. The encoded protein interacts with dopamine receptor D1 and may interact with other DA receptor subtypes and/or GPCRs.

Interactions

• SPARCL1 (hevin)^[3]

Further reading

• Milligan G, White JH . Protein-protein interactions at G-protein-coupled receptors . Trends in Pharmacological Sciences . 22 . 10 . 513–8 . October 2001 . 11583808 . 10.1016/S0165-6147(00)01801-0 .
• Ali MK, Bergson C . Elevated intracellular calcium triggers recruitment of the receptor cross-talk accessory protein calcyon to the plasma membrane . The Journal of Biological Chemistry . 278 . 51 . 51654–63 . December 2003 . 14534309 . 10.1074/jbc.M305803200 . free .
• Luo X, Kranzler H, Lappalainen J, Rosenheck R, Charney D, Zuo L, Erdos J, van Kammen DP, Gelernter J . CALCYON gene variation, schizophrenia, and cocaine dependence . American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics . 125B . 1 . 25–30 . February 2004 . 14755439 . 10.1002/ajmg.b.20092 . 24881261 . free .
• Laurin N, Misener VL, Crosbie J, Ickowicz A, Pathare T, Roberts W, Malone M, Tannock R, Schachar R, Kennedy JL, Barr CL . Association of the calcyon gene (DRD1IP) with attention deficit/hyperactivity disorder . Molecular Psychiatry . 10 . 12 . 1117–25 . December 2005 . 16172615 . 10.1038/sj.mp.4001737 . 25367235 .
• Xiao J, Dai R, Negyessy L, Bergson C . Calcyon, a novel partner of clathrin light chain, stimulates clathrin-mediated endocytosis . The Journal of Biological Chemistry . 281 . 22 . 15182–93 . June 2006 . 16595675 . 10.1074/jbc.M600265200 . free .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . November 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Kruusmägi M, Zelenin S, Brismar H, Scott L . Intracellular dynamics of calcyon, a neuron-specific vesicular protein . NeuroReport . 18 . 15 . 1547–51 . October 2007 . 17885599 . 10.1097/WNR.0b013e3282f03f51 . 24544827 .

Notes and References

1. Heijtz RD, Alexeyenko A, Castellanos FX . Calcyon mRNA expression in the frontal-striatal circuitry and its relationship to vesicular processes and ADHD . Behavioral and Brain Functions . 3 . 1 . 33 . July 2007 . 17623072 . 1949817 . 10.1186/1744-9081-3-33 . free .
2. Web site: CALY calcyon neuron specific vesicular protein [Homo sapiens (human) ]].
3. Kim JH, Jung HG, Kim A, Shim HS, Hyeon SJ, Lee YS, Han J, Jung JH, Lee J, Ryu H, Park JY, Hwang EM, Suk K . 6 . Hevin-calcyon interaction promotes synaptic reorganization after brain injury . Cell Death and Differentiation . March 2021 . 28 . 9 . 2571–2588 . 33753902 . 10.1038/s41418-021-00772-5 . 8408247 . free .