Calumenin Explained

Calumenin is a protein that in humans is encoded by the CALU gene.^{[1] [2]}

Calumenin (CALU) is a calcium-binding protein localized in the endoplasmic reticulum (ER) and is involved in such ER functions as protein folding and sorting. Calumenin is a member of the EF-hand superfamily in the ER and Golgi apparatus named CERC. CERC is an acronym for its family members Cab-45, reticulocalbin, Erc-55 (RCN2), and calumenin. The CALU gene encodes a deduced 315-amino acid protein containing 6 EF-hand motifs, 1 potential N-glycosylation site, and a C-terminal ER retention signal. The human and mouse CALU proteins are 98% identical. CALU mRNA is ubiquitously expressed in human tissues and maps to 7q32.

Further reading

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Notes and References

1. Yabe D, Taniwaki M, Nakamura T, Kanazawa N, Tashiro K, Honjo T . Human calumenin gene (CALU): cDNA isolation and chromosomal mapping to 7q32 . Genomics . 49 . 2 . 331–3 . Aug 1998 . 9598325 . 10.1006/geno.1998.5245 .
2. Web site: Entrez Gene: CALU calumenin.