CALN1 explained

Calcium-binding protein 8 is a protein that in humans is encoded by the CALN1 gene.^{[1] [2]} Alternative splicing results in multiple transcript variants.^[2]

Function

This gene encodes a protein with high similarity to the calcium-binding proteins of the calmodulin family. The encoded protein contains two EF-hand domains and potential calcium-binding sites.^[3]

Further reading

• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA . A "double adaptor" method for improved shotgun library construction . Analytical Biochemistry . 236 . 1 . 107–13 . Apr 1996 . 8619474 . 10.1006/abio.1996.0138 .
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA . Large-scale concatenation cDNA sequencing . Genome Research . 7 . 4 . 353–8 . Apr 1997 . 9110174 . 139146 . 10.1101/gr.7.4.353 .
• Toward a complete human genome sequence . Genome Research . 8 . 11 . 1097–108 . Nov 1998 . 9847074 . 10.1101/gr.8.11.1097 . free . Sanger Centre . The . Washington University Genome Sequencing Cente . The .

Notes and References

1. Wu YQ, Lin X, Liu CM, Jamrich M, Shaffer LG . Identification of a human brain-specific gene, calneuron 1, a new member of the calmodulin superfamily . Molecular Genetics and Metabolism . 72 . 4 . 343–50 . Apr 2001 . 11286509 . 10.1006/mgme.2001.3160 .
2. Web site: Entrez Gene: CALN1 calneuron 1.
3. McCue HV, Haynes LP, Burgoyne RD . The diversity of calcium sensor proteins in the regulation of neuronal function . Cold Spring Harbor Perspectives in Biology . 2 . 8 . a004085 . Aug 2010 . 20668007 . 2908765 . 10.1101/cshperspect.a004085 .