CALML5 explained

Calmodulin-like protein 5 is a protein that in humans is encoded by the CALML5 gene.^{[1] [2]}

This gene encodes a novel calcium binding protein expressed in the epidermis and related to the calmodulin family of calcium binding proteins. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so. Abundant expression is detected only in reconstructed epidermis and is restricted to differentiating keratinocytes. In addition, it can associate with transglutaminase 3, shown to be a key enzyme in the terminal differentiation of keratinocytes.

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Méhul B, Bernard D, Schmidt R . Calmodulin-like skin protein: a new marker of keratinocyte differentiation . J. Invest. Dermatol. . 116 . 6 . 905–9 . 2001 . 11407979 . 10.1046/j.0022-202x.2001.01376.x . free .
• Durussel I, Méhul B, Bernard D . Cation- and peptide-binding properties of human calmodulin-like skin protein . Biochemistry . 41 . 17 . 5439–48 . 2002 . 11969404 . 10.1021/bi016062z . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . etal.
• Méhul B, Bernard D, Brouard M . Influence of calcium on the proteolytic degradation of the calmodulin-like skin protein (calmodulin-like protein 5) in psoriatic epidermis . Exp. Dermatol. . 15 . 6 . 469–77 . 2006 . 16689864 . 10.1111/j.1600-0625.2006.00433.x . 32717375 . etal.
• Babini E, Bertini I, Capozzi F . A structural and dynamic characterization of the EF-hand protein CLSP . Structure . 14 . 6 . 1029–38 . 2006 . 16765896 . 10.1016/j.str.2006.04.004 . etal. free .
• Ewing RM, Chu P, Elisma F . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 . etal.

Notes and References

1. Mehul B, Bernard D, Simonetti L, Bernard MA, Schmidt R . Identification and cloning of a new calmodulin-like protein from human epidermis . J Biol Chem . 275 . 17 . 12841–7 . Jun 2000 . 10777582 . 10.1074/jbc.275.17.12841 . free .
2. Web site: Entrez Gene: CALML5 calmodulin-like 5.