Calbindin 1 Explained

Calbindin 1 is a protein that in humans is encoded by the CALB1 gene. It belongs to the calbindin family of calcium-binding proteins, along with calretinin (CALB2).^[1]

Function

The protein encoded by this gene is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. Originally described as a 27 kDa protein, it is now known to be a 28 kDa protein. It contains four active calcium-binding domains, and has two modified domains that are thought to have lost their calcium binding capability.^[2] This protein is thought to buffer entry of calcium upon stimulation of glutamate receptors. Depletion of this protein was noted in patients with Huntington disease. [provided by RefSeq, Jan 2015].

Further reading

• Tao L, Murphy ME, English AM . S-nitrosation of Ca(2+)-loaded and Ca(2+)-free recombinant calbindin D(28K) from human brain . Biochemistry . 41 . 19 . 6185–92 . May 2002 . 11994015. 10.1021/bi015846+.
• Berggard T, Szczepankiewicz O, Thulin E, Linse S . Myo-inositol monophosphatase is an activated target of calbindin D28k . J. Biol. Chem. . 277 . 44 . 41954–9 . November 2002 . 12176979 . 10.1074/jbc.M203492200 . free .
• Belkacemi L, Gariépy G, Mounier C, Simoneau L, Lafond J . Expression of calbindin-D28k (CaBP28k) in trophoblasts from human term placenta . Biol. Reprod. . 68 . 6 . 1943–50 . June 2003 . 12606474 . 10.1095/biolreprod.102.009373 .
• Cedervall T, Berggård T, Borek V, Thulin E, Linse S, Akerfeldt KS . Redox sensitive cysteine residues in calbindin D28k are structurally and functionally important . Biochemistry . 44 . 2 . 684–93 . January 2005 . 15641794 . 10.1021/bi049232r .
• Vanbelle C, Halgand F, Cedervall T, Thulin E, Akerfeldt KS, Laprévote O, Linse S . Deamidation and disulfide bridge formation in human calbindin D28k with effects on calcium binding . Protein Sci. . 14 . 4 . 968–79 . April 2005 . 15741335 . 2253450 . 10.1110/ps.041157705 .
• Valencia I, Legido A, Yelin K, Khurana D, Kothare SV, Katsetos CD . Anomalous inhibitory circuits in cortical tubers of human tuberous sclerosis complex associated with refractory epilepsy: aberrant expression of parvalbumin and calbindin-D28k in dysplastic cortex . J. Child Neurol. . 21 . 12 . 1058–63 . December 2006 . 17156698 . 10.1177/7010.2006.00242 . 36971471 .
• Vig PJ, Wei J, Shao Q, Hebert MD, Subramony SH, Sutton LT . Role of tissue transglutaminase type 2 in calbindin-D28k interaction with ataxin-1 . Neurosci. Lett. . 420 . 1 . 53–7 . June 2007 . 17442486 . 1949022 . 10.1016/j.neulet.2007.04.005 .
• Zhang C, Sun Y, Wang W, Zhang Y, Ma M, Lou Z . Crystallization and preliminary crystallographic analysis of human Ca 2+-loaded calbindin-D28k . Acta Crystallographica Section F . 64 . Pt 2 . 133–6 . February 2008 . 18259068 . 2374171 . 10.1107/S1744309108001905 .
• Bauer MC, Nilsson H, Thulin E, Frohm B, Malm J, Linse S . Zn2+ binding to human calbindin D(28k) and the role of histidine residues . Protein Sci. . 17 . 4 . 760–7 . April 2008 . 18359862 . 2271158 . 10.1110/ps.073381108 .

Notes and References

1. Web site: Entrez Gene: Calbindin 1. 2018-10-04.
2. Noble JW, Almalki R, Roe SM, Wagner A, Duman R, Atack JR . The X-ray structure of human calbindin-D28K: an improved model . Acta Crystallographica Section D . 74 . Pt 10 . 1008–1014 . October 2018 . 30289411 . 6173056 . 10.1107/s2059798318011610 . 2018AcCrD..74.1008N .