| Tourney Name: | CAF Confederation Cup |
| Year: | 2010 |
| Other Titles: | Confederation of African Football Confederation Cup |
| Size: | 130px |
| Dates: | February 2010 – November |
| Num Teams: | 52 |
| Champion Other: |  FUS Rabat |
| Count: | 1 |
| Second Other: |  CS Sfaxien |
| Matches: | 116 |
| Goals: | 297 |
| Prevseason: | 2009 |
| Nextseason: | 2011 |
The 2010 CAF Confederation Cup was the 7th edition of the CAF Confederation Cup, Africa's secondary club football competition organized by the Confederation of African Football (CAF). The winners played in the 2011 CAF Super Cup.
| Round | 1st leg | 2nd leg | |
|---|---|---|---|
| Preliminary round | 12–14 February | 26–28 February | |
| First round | 19–21 March | 2–4 April | |
| Second round (1st Round of 16) | 23–25 April | 7–9 May | |
| Play-off for group stage (2nd Round of 16) | 16–18 July | 30 July–1 August | |
| Group stage | 13–15 August 27–29 August 10–12 September 17–19 September 1–3 October 15–17 October | ||
| Semifinals | 29–31 October | 12–14 November | |
| Final | 26–28 November | 3–5 December | |
|}
Byes: Primeiro de Agosto (Angola), Coton Sport FC (Cameroon), Haras El Hodood (Egypt), FC 105 (Gabon), FAR Rabat (Morocco), Stade Malien (Mali), Enyimba (Nigeria), AS Vita Club (Congo DR), Simba (Tanzania), Étoile Sahel (Tunisia), CS Sfaxien (Tunisia), ZESCO United (Zambia), Académica do Soyo (Angola)2, Panthère Sportive du Ndé FC (Cameroon) 3.
1 SC Villa withdrew.
2 Académica do Soyo were drawn against the champions of São Tomé and Príncipe, but the São Toméan FA did not send a team.
3 Panthère du Ndé were drawn against the champions of Benin, but the Beninese FA did not send a team.
|}
|}The Winners advance to a play-off against the losers of the Second Round of the Champions League
|}The Winners advanced to the Group Stage
See main article: 2010 CAF Confederation Cup group stage.
See main article: 2010 CAF Confederation Cup knock-out stage.
|}
See main article: 2010 CAF Confederation Cup Final.
FUS Rabat won 3 - 2 on aggregate.
The top scorers from the 2010 CAF Confederation Cup are as follows:
| Rank | Name | Team | Goals |
|---|---|---|---|
| 1 |  Ahmed Abdel-Ghani | Haras El Hodood | 7 |
| 2 | Al-Tahir Hamad | Al-Amal Atbara | 5 |
| Edward Sadomba | Al-Hilal | 5 | |
| Hamza Younés | CS Sfaxien | 5 |