| Tourney Name: | CAF Confederation Cup |
| Year: | 2004 |
| Other Titles: | Confederation of African Football Confederation Cup |
| Size: | 130px |
| Dates: | 6 March 2004 – 9 January |
| Num Teams: | 55 |
| Champion Other: |  Hearts of Oak |
| Count: | 1 |
| Second Other: | Asante Kotoko |
| Matches: | 104 |
| Goals: | 299 |
| Top Scorer: | Ugochukwu Okeke Christopher Katongo (5 goals each) |
| Prevseason: | 2003 (CAF Cup) |
| Nextseason: | 2005 |
The 2004 CAF Confederation Cup was the first edition of the newly created CAF Confederation Cup. Hearts of Oak of Ghana beat fellow Ghanaians Asante Kotoko 8-7 on penalties in the final after the two legs ended 2-2.
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1 Mtibwa Sugar withdrew before the 2nd leg. but mtibwa sugar was seemed to be challenging team in Tanzania
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In this round, the 8 winners of the round of 16 play the losers of the round of 16 of the Champions League for 8 places in the group stage.
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See main article: 2004 CAF Confederation Cup group stage.
The top scorers from the 2004 CAF Confederation Cup are as follows:
| Rank | Name | Team | Goals |
|---|---|---|---|
| 1 | Ugochukwu Okeke | Enugu Rangers | 5 |
| Christopher Katongo | Green Buffaloes | 5 | |
| 2 | Flávio | Petro de Luanda | 4 |
 Herman Dzumafo | Sable FC | 4 | |
| Bernard Ngom | Sable FC | 4 | |
| Eric Gawu | King Faisal Babes | 4 | |
 Ahmed Saad | Al-Nasr | 4 | |
| Francky Randrianasoliana | Léopards de Transfoot | 4 | |
| Jimmy Mumba | Green Buffaloes | 4 |