| Tourney Name: | CAF Champions League |
| Year: | 2001 |
| Size: | 200px |
| Dates: | 18 February – 21 December |
| Num Teams: | 39 |
| Associations: | 39 |
| Champion Other: |  Al Ahly |
| Count: | 3 |
| Second Other: | Mamelodi Sundowns |
| Matches: | 92 |
| Goals: | 224 |
| Prevseason: | 2000 |
| Nextseason: | 2002 |
The 2001 CAF Champions League was the 37th awarding of Africa's premier club football tournament prize organized by the Confederation of African Football (CAF), and the 5th prize under the CAF Champions League format.
In the knockout stage, was added the semifinal rounds so that the runners up as well as the winners from the group stage would progress. In the final, Al Ahly of Egypt defeated Mamelodi Sundowns of South Africa to win their third title.
1 The match was abandoned at 80' with Young Africans leading 2–0 and about to take a penalty, after local fans hurled plastic chairs onto the pitch and at the players and officials.
See main article: 2001 CAF Champions League group stage.
See main article: 2001 CAF Champions League Final.
The top scorers from the 2001 CAF Champions League are as follows:
| Rank | Name | Team | Goals |
|---|---|---|---|
| 1 |  Kapela Mbiyavanga | Petro Atlético | 9 |
| 2 | Flávio | Petro Atlético | 7 |
| 3 | Khaled Bebo | Al Ahly | 6 |
| 4 | Avelino Lopes | Petro Atlético | 5 |
| Alaa Ibrahim | Al Ahly | ||
| 6 | Patrick Lolo | Étoile du Congo | 4 |
 Emmanuel Osei Kuffour | Hearts of Oak | ||
 Antonin Koutouan | ASEC Mimosas | ||
| Oluwasegun Abiodun | Julius Berger | ||
 Adailton |  ES Tunis | ||
| Reinaldo | ES Tunis | ||
| Mourad Melki | ES Tunis |