CADM3 explained

Cell adhesion molecule 3 is a protein that in humans is encoded by the CADM3 gene.^{[1] [2]}

IGSF4B is a brain-specific protein related to the calcium-independent cell-cell adhesion molecules known as nectins (see PVRL3; MIM 607147) (Kakunaga et al., 2005).

Further reading

• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Shingai T, Ikeda W, Kakunaga S . Implications of nectin-like molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells . J. Biol. Chem. . 278 . 37 . 35421–7 . 2003 . 12826663 . 10.1074/jbc.M305387200 . etal. free .
• Clark HF, Gurney AL, Abaya E . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 . etal.
• Fukami T, Satoh H, Williams YN . Isolation of the mouse Tsll1 and Tsll2 genes, orthologues of the human TSLC1-like genes 1 and 2 (TSLL1 and TSLL2) . Gene . 323 . 11–8 . 2004 . 14659875 . 10.1016/j.gene.2003.09.018 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Zhang Z, Henzel WJ . Signal peptide prediction based on analysis of experimentally verified cleavage sites . Protein Sci. . 13 . 10 . 2819–24 . 2005 . 15340161 . 10.1110/ps.04682504 . 2286551 .
• Kakunaga S, Ikeda W, Itoh S . Nectin-like molecule-1/TSLL1/SynCAM3: a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule localizing at non-junctional contact sites of presynaptic nerve terminals, axons and glia cell processes . J. Cell Sci. . 118 . Pt 6 . 1267–77 . 2005 . 15741237 . 10.1242/jcs.01656 . etal. 18949720 .
• Zhou Y, Du G, Hu X . Nectin-like molecule 1 is a protein 4.1N associated protein and recruits protein 4.1N from cytoplasm to the plasma membrane . Biochim. Biophys. Acta . 1669 . 2 . 142–54 . 2005 . 15893517 . 10.1016/j.bbamem.2005.01.013 . etal.
• Dong X, Xu F, Gong Y . Crystal structure of the V domain of human Nectin-like molecule-1/Syncam3/Tsll1/Igsf4b, a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule . J. Biol. Chem. . 281 . 15 . 10610–7 . 2006 . 16467305 . 10.1074/jbc.M513459200 . etal. free .
• Gregory SG, Barlow KF, McLay KE . The DNA sequence and biological annotation of human chromosome 1 . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . etal. free .

Notes and References

1. Fukuhara H, Kuramochi M, Nobukuni T, Fukami T, Saino M, Maruyama T, Nomura S, Sekiya T, Murakami Y . Isolation of the TSLL1 and TSLL2 genes, members of the tumor suppressor TSLC1 gene family encoding transmembrane proteins . Oncogene . 20 . 38 . 5401–7 . Sep 2001 . 11536053 . 10.1038/sj.onc.1204696 . 6564286 .
2. Web site: Entrez Gene: CADM3 cell adhesion molecule 3.