CACYBP explained

Calcyclin-binding protein is a protein that in humans is encoded by the CACYBP gene.^{[1] [2] [3]}

The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.^[3]

Protein Interactions

CACYBP has been shown to interact with SKP1A^[4] and SIAH1.^[1]

The CacyBP/SIP complex instead, is known to be a part of stress respons, since it interacts with chaperone HSP90.^[5]

Further reading

• Filipek A, Jastrzebska B, Nowotny M, Kwiatkowska K, Hetman M, Surmacz L, Wyroba E, Kuznicki J . 6 . Ca2+-dependent translocation of the calcyclin-binding protein in neurons and neuroblastoma NB-2a cells . The Journal of Biological Chemistry . 277 . 23 . 21103–9 . June 2002 . 11927578 . 10.1074/jbc.M111010200 . free .
• Liu WX, Wu J, Zhao Z, Zhou Y, Peng XZ, Yuan JG, Qiang BQ . [Cloning and expression of human calcyclin binding protein (hCacyBP) gene] . Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica et Biophysica Sinica . 34 . 2 . 181–6 . March 2002 . 12006993 .
• Filipek A, Jastrzebska B, Nowotny M, Kuznicki J . CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family . The Journal of Biological Chemistry . 277 . 32 . 28848–52 . August 2002 . 12042313 . 10.1074/jbc.M203602200 . free .
• Wu J, Tan X, Peng X, Yuan J, Qiang B . Translocation and phosphorylation of calcyclin binding protein during retinoic acid-induced neuronal differentiation of neuroblastoma SH-SY5Y cells . Journal of Biochemistry and Molecular Biology . 36 . 4 . 354–8 . July 2003 . 12895292 . 10.5483/bmbrep.2003.36.4.354 . free .
• Santelli E, Leone M, Li C, Fukushima T, Preece NE, Olson AJ, Ely KR, Reed JC, Pellecchia M, Liddington RC, Matsuzawa S . 6 . Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex . The Journal of Biological Chemistry . 280 . 40 . 34278–87 . October 2005 . 16085652 . 10.1074/jbc.M506707200 . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . 6 . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . October 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . 6 . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .
• Sun S, Ning X, Liu J, Liu L, Chen Y, Han S, Zhang Y, Liang J, Wu K, Fan D . 6 . Overexpressed CacyBP/SIP leads to the suppression of growth in renal cell carcinoma . Biochemical and Biophysical Research Communications . 356 . 4 . 864–71 . May 2007 . 17400182 . 10.1016/j.bbrc.2007.03.080 .

Notes and References

1. Matsuzawa SI, Reed JC . Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses . Molecular Cell . 7 . 5 . 915–26 . May 2001 . 11389839 . 10.1016/S1097-2765(01)00242-8 . free .
2. Matsuzawa S, Li C, Ni CZ, Takayama S, Reed JC, Ely KR . Structural analysis of Siah1 and its interactions with Siah-interacting protein (SIP) . The Journal of Biological Chemistry . 278 . 3 . 1837–40 . January 2003 . 12421809 . 10.1074/jbc.M210263200 . free .
3. Web site: Entrez Gene: CACYBP calcyclin binding protein.
4. Matsuzawa SI, Reed JC . Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses . Molecular Cell . 7 . 5 . 915–26 . May 2001 . 11389839 . 10.1016/S1097-2765(01)00242-8 . free .
5. Filipek. Anna. Leśniak. Wiesława. 2018-12-29. Aktualny pogląd na komórkową funkcję S100A6 i jego ligandów, CacyBP/SIP i Sgt1. Postępy Biochemii. pl. 64. 3. 242–252. 10.18388/pb.2018_136. 30656909. 0032-5422. free.