CACNG4 explained

Voltage-dependent calcium channel gamma-4 subunit is a protein that in humans is encoded by the CACNG4 gene.^{[1] [2]}

L-type calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of several gamma subunit proteins. It is an integral membrane protein that is thought to stabilize the calcium channel in an inactive (closed) state. This gene is a member of the neuronal calcium channel gamma subunit gene subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two similar gamma subunit-encoding genes.

See also

• Voltage-dependent calcium channel

Further reading

• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Moss FJ, Dolphin AC, Clare JJ . Human neuronal stargazin-like proteins, γ2, γ3 and γ4; an investigation of their specific localization in human brain and their influence on CaV2.1 voltage-dependent calcium channels expressed in Xenopus oocytes . BMC Neuroscience . 4. 23 . 2004 . 14505496 . 10.1186/1471-2202-4-23 . 270087 . free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Chu PJ, Robertson HM, Best PM . Calcium channel gamma subunits provide insights into the evolution of this gene family . Gene . 280 . 1–2 . 37–48 . 2002 . 11738816 . 10.1016/S0378-1119(01)00738-7 .
• Burgess DL, Gefrides LA, Foreman PJ, Noebels JL . A cluster of three novel Ca2+ channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family . Genomics . 71 . 3 . 339–50 . 2001 . 11170751 . 10.1006/geno.2000.6440 .
• Powers PA, Liu S, Hogan K, Gregg RG . Molecular characterization of the gene encoding the gamma subunit of the human skeletal muscle 1,4-dihydropyridine-sensitive Ca2+ channel (CACNLG), cDNA sequence, gene structure, and chromosomal location . J. Biol. Chem. . 268 . 13 . 9275–9 . 1993 . 10.1016/S0021-9258(18)98346-8 . 8387489 . free .

Notes and References

1. Burgess DL, Davis CF, Gefrides LA, Noebels JL . Identification of Three Novel Ca2+ Channel γ Subunit Genes Reveals Molecular Diversification by Tandem and Chromosome Duplication . Genome Res . 9 . 12 . 1204–13 . Jan 2000 . 10613843 . 311002 . 10.1101/gr.9.12.1204 .
2. Web site: Entrez Gene: CACNG4 calcium channel, voltage-dependent, gamma subunit 4.