CACNA1B explained

The voltage-dependent N-type calcium channel subunit alpha-1B is a protein that in humans is encoded by the CACNA1B gene.^{[1] [2] [3]} The α1B protein, together with β and α2δ subunits forms N-type calcium channel (Ca_v2.2 channel).^[4] It is a R-type calcium channel.

Further reading

• Mould J, Yasuda T, Schroeder CI, Beedle AM, Doering CJ, Zamponi GW, Adams DJ, Lewis RJ . The alpha2delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Cav2.2) calcium channels . The Journal of Biological Chemistry . 279 . 33 . 34705–34714 . August 2004 . 15166237 . 10.1074/jbc.M310848200 . free .
• Park SY, Park YT, Kim KE, Rhee MC, Cho HJ, Kim DS . A direct repeat of N-type Ca2+ channel alpha1B gene functions as a negative regulatory element in HeLa cells . Molecules and Cells . 13 . 2 . 341–346 . April 2002 . 12018859 . 10.1016/S1016-8478(23)15043-6 . free .
• Calabrese B, Tabarean IV, Juranka P, Morris CE . Mechanosensitivity of N-type calcium channel currents . Biophysical Journal . 83 . 5 . 2560–2574 . November 2002 . 12414690 . 1302342 . 10.1016/S0006-3495(02)75267-3 . 2002BpJ....83.2560C .
• Moskvina V, Craddock N, Holmans P, Nikolov I, Pahwa JS, Green E, Owen MJ, O'Donovan MC . Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk . Molecular Psychiatry . 14 . 3 . 252–260 . March 2009 . 19065143 . 3970088 . 10.1038/mp.2008.133 .
• Castiglioni AJ, Raingo J, Lipscombe D . Alternative splicing in the C-terminus of CaV2.2 controls expression and gating of N-type calcium channels . The Journal of Physiology . 576 . Pt 1 . 119–134 . October 2006 . 16857708 . 1995641 . 10.1113/jphysiol.2006.115030 .
• Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J . International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels . Pharmacological Reviews . 57 . 4 . 411–425 . December 2005 . 16382099 . 10.1124/pr.57.4.5 . 10386627 .
• Yokoyama CT, Myers SJ, Fu J, Mockus SM, Scheuer T, Catterall WA . Mechanism of SNARE protein binding and regulation of Cav2 channels by phosphorylation of the synaptic protein interaction site . Molecular and Cellular Neurosciences . 28 . 1 . 1–17 . January 2005 . 15607937 . 10.1016/j.mcn.2004.08.019 . 38370138 .
• Maeno-Hikichi Y, Chang S, Matsumura K, Lai M, Lin H, Nakagawa N, Kuroda S, Zhang JF . A PKC epsilon-ENH-channel complex specifically modulates N-type Ca2+ channels . Nature Neuroscience . 6 . 5 . 468–475 . May 2003 . 12665800 . 10.1038/nn1041 . 19964052 .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–648 . November 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Li D, Wang F, Lai M, Chen Y, Zhang JF . A protein phosphatase 2calpha-Ca2+ channel complex for dephosphorylation of neuronal Ca2+ channels phosphorylated by protein kinase C . The Journal of Neuroscience . 25 . 8 . 1914–1923 . February 2005 . 15728831 . 6726054 . 10.1523/JNEUROSCI.4790-04.2005 .
• Butcher AJ, Leroy J, Richards MW, Pratt WS, Dolphin AC . The importance of occupancy rather than affinity of CaV(beta) subunits for the calcium channel I-II linker in relation to calcium channel function . The Journal of Physiology . 574 . Pt 2 . 387–398 . July 2006 . 16627564 . 1817768 . 10.1113/jphysiol.2006.109744 .
• Stotz SC, Barr W, McRory JE, Chen L, Jarvis SE, Zamponi GW . Several structural domains contribute to the regulation of N-type calcium channel inactivation by the beta 3 subunit . The Journal of Biological Chemistry . 279 . 5 . 3793–3800 . January 2004 . 14602720 . 10.1074/jbc.M308991200 . free .
• Maximov A, Bezprozvanny I . Synaptic targeting of N-type calcium channels in hippocampal neurons . The Journal of Neuroscience . 22 . 16 . 6939–6952 . August 2002 . 12177192 . 3307533 . 10.1523/JNEUROSCI.22-16-06939.2002 .
• Peng S, Hajela RK, Atchison WD . Characteristics of block by Pb2+ of function of human neuronal L-, N-, and R-type Ca2+ channels transiently expressed in human embryonic kidney 293 cells . Molecular Pharmacology . 62 . 6 . 1418–1430 . December 2002 . 12435810 . 10.1124/mol.62.6.1418 .
• Murakami M, Fleischmann B, De Felipe C, Freichel M, Trost C, Ludwig A, Wissenbach U, Schwegler H, Hofmann F, Hescheler J, Flockerzi V, Cavalié A . Pain perception in mice lacking the beta3 subunit of voltage-activated calcium channels . The Journal of Biological Chemistry . 277 . 43 . 40342–40351 . October 2002 . 12161429 . 10.1074/jbc.M203425200 . free . free . 10261/310195 .
• Vitko I, Shcheglovitov A, Baumgart JP, Arias-Olguín II, Murbartián J, Arias JM, Perez-Reyes E . Orientation of the calcium channel beta relative to the alpha(1)2.2 subunit is critical for its regulation of channel activity . PLOS ONE . 3 . 10 . e3560 . 2008 . 18958281 . 2570331 . 10.1371/journal.pone.0003560 . Schwartz . free . 2008PLoSO...3.3560V . Arnold .
• Coppola T, Magnin-Luthi S, Perret-Menoud V, Gattesco S, Schiavo G, Regazzi R . Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin . The Journal of Biological Chemistry . 276 . 35 . 32756–32762 . August 2001 . 11438518 . 10.1074/jbc.M100929200 . free .
• Johnson JM, Castle J, Garrett-Engele P, Kan Z, Loerch PM, Armour CD, Santos R, Schadt EE, Stoughton R, Shoemaker DD . Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays . Science . 302 . 5653 . 2141–2144 . December 2003 . 14684825 . 10.1126/science.1090100 . 10007258 . 2003Sci...302.2141J .
• Agler HL, Evans J, Tay LH, Anderson MJ, Colecraft HM, Yue DT . G protein-gated inhibitory module of N-type (ca(v)2.2) ca2+ channels . Neuron . 46 . 6 . 891–904 . June 2005 . 15953418 . 10.1016/j.neuron.2005.05.011 . 16963916 . free .

Notes and References

1. Web site: Entrez Gene: CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit .
2. Diriong S, Lory P, Williams ME, Ellis SB, Harpold MM, Taviaux S . Chromosomal localization of the human genes for alpha 1A, alpha 1B, and alpha 1E voltage-dependent Ca2+ channel subunits . Genomics . 30 . 3 . 605–609 . December 1995 . 8825650 . 10.1006/geno.1995.1284 .
3. Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J . International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels . Pharmacological Reviews . 57 . 4 . 411–425 . December 2005 . 16382099 . 10.1124/pr.57.4.5 . 10386627 .
4. Heyes S, Pratt WS, Rees E, Dahimene S, Ferron L, Owen MJ, Dolphin AC . Genetic disruption of voltage-gated calcium channels in psychiatric and neurological disorders . Progress in Neurobiology . 134 . 36–54 . November 2015 . 26386135 . 4658333 . 10.1016/j.pneurobio.2015.09.002 .