CABYR explained

Calcium-binding tyrosine phosphorylation-regulated protein is a protein that in humans is encoded by the CABYR gene.^{[1] [2] [3] [4]}

To reach fertilization competence, spermatozoa undergo a series of morphological and molecular maturational processes, termed capacitation, involving protein tyrosine phosphorylation and increased intracellular calcium. The protein encoded by this gene localizes to the principal piece of the sperm flagellum in association with the fibrous sheath and exhibits calcium-binding when phosphorylated during capacitation. A pseudogene on chromosome 3 has been identified for this gene. Transcript variants of this gene encode multiple protein isoforms. An additional transcript and isoform has not been fully characterized.

Further reading

• The cytoskeleton of mammalian spermatozoa . Biol. Cell . 81 . 2 . 89–93 . 1995 . 7849610 . 10.1016/S0248-4900(94)80001-4 . Fouquet JP . Kann ML . 39352537 .
• Novel signaling pathways involved in sperm acquisition of fertilizing capacity . J. Reprod. Immunol. . 53 . 1–2 . 133–50 . 2002 . 11730911 . 10.1016/S0165-0378(01)00103-6 . 3 . Visconti PE . Westbrook VA . Chertihin O . vanc . Demarco . I . Sleight . S . Diekman . AB .
• Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 . Maruyama K . Sugano S .
• Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . 3 . Suzuki Y . Yoshitomo-Nakagawa K . Maruyama K . vanc . Suyama . A . Sugano . S .
• Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 3 . Strausberg RL . Feingold EA . Grouse LH . vanc . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 139241 . 2002PNAS...9916899M . free .
• Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation . J. Biol. Chem. . 278 . 13 . 11579–89 . 2003 . 12509440 . 10.1074/jbc.M202325200 . 3 . Ficarro S . Chertihin O . Westbrook VA . vanc . White . F . Jayes . F . Kalab . P . Marto . JA . Shabanowitz . J . Herr . JC . free .
• The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 3 . Gerhard DS . Wagner L . Feingold EA . vanc . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R . 528928 .
• Characterization of two non-testis-specific CABYR variants that bind to GSK3beta with a proline-rich extensin-like domain . Biochem. Biophys. Res. Commun. . 329 . 3 . 1108–17 . 2005 . 15752768 . 10.1016/j.bbrc.2005.02.089 . 3 . Hsu HC . Lee YL . Cheng TS . vanc . Howng . SL . Chang . LK . Lu . PJ . Hong . YR .

Notes and References

1. Naaby-Hansen S, Mandal A, Wolkowicz MJ, Sen B, Westbrook VA, Shetty J, Coonrod SA, Klotz KL, Kim YH, Bush LA, Flickinger CJ, Herr JC . CABYR, a novel calcium-binding tyrosine phosphorylation-regulated fibrous sheath protein involved in capacitation . Dev Biol . 242 . 2 . 236–54 . Jan 2002 . 11820818 . 10.1006/dbio.2001.0527 . free .
2. Luo C, Xiao X, Liu D, Chen S, Li M, Xu A, Liu J, Gao S, Wu S, He D . CABYR is a novel cancer-testis antigen in lung cancer . Clin Cancer Res . 13 . 4 . 1288–97 . Feb 2007 . 17317841 . 10.1158/1078-0432.CCR-06-1742 . free .
3. Kim YH, Jha KN, Mandal A, Vanage G, Farris E, Snow PL, Klotz K, Naaby-Hansen S, Flickinger CJ, Herr JC . Translation and assembly of CABYR coding region B in fibrous sheath and restriction of calcium binding to coding region A . Dev Biol . 286 . 1 . 46–56 . Oct 2005 . 16139264 . 10.1016/j.ydbio.2005.07.005 . free .
4. Web site: Entrez Gene: CABYR calcium binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2).