CABLES1 explained

CDK5 and ABL1 enzyme substrate 1 is a protein that in humans is encoded by the CABLES1 gene.^{[1] [2]}

CABLES1 is a cyclin-dependent kinase (CDK)-binding protein that plays a role in proliferation and/or cell differentiation (Zukerberg et al., 2004).[supplied by OMIM].^[2] It is a tumor suppressor gene which losing it (by mutations, knockout, knockdown or inactivation) may lead to colorectal cancer CRC.

Further reading

• Matsuoka M, Matsuura Y, Semba K, Nishimoto I . Molecular cloning of a cyclin-like protein associated with cyclin-dependent kinase 3 (cdk 3) in vivo. . Biochem. Biophys. Res. Commun. . 273 . 2 . 442–7 . 2000 . 10873625 . 10.1006/bbrc.2000.2965 .
• Zukerberg LR, Patrick GN, Nikolic M . Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth. . Neuron . 26 . 3 . 633–46 . 2000 . 10896159 . 10.1016/S0896-6273(00)81200-3 . 1721.1/83489 . 15142577 . etal. free .
• Yamochi T, Nishimoto I, Okuda T, Matsuoka M . ik3-1/Cables is associated with Trap and Pctaire2. . Biochem. Biophys. Res. Commun. . 286 . 5 . 1045–50 . 2001 . 11527406 . 10.1006/bbrc.2001.5493 .
• Wu CL, Kirley SD, Xiao H . Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers. . Cancer Res. . 61 . 19 . 7325–32 . 2001 . 11585773 . etal.
• Tsuji K, Mizumoto K, Yamochi T . Differential effect of ik3-1/cables on p53- and p73-induced cell death. . J. Biol. Chem. . 277 . 4 . 2951–7 . 2002 . 11706030 . 10.1074/jbc.M108535200 . etal. free .
• Yamochi T, Semba K, Tsuji K . ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3). . Eur. J. Biochem. . 268 . 23 . 6076–82 . 2002 . 11733001 . 10.1046/j.0014-2956.2001.02555.x . etal.
• Sato H, Nishimoto I, Matsuoka M . ik3-2, a relative to ik3-1/cables, is associated with cdk3, cdk5, and c-abl. . Biochim. Biophys. Acta . 1574 . 2 . 157–63 . 2002 . 11955625 . 10.1016/S0167-4781(01)00367-0.
• Tan D, Kirley S, Li Q . Loss of cables protein expression in human non-small cell lung cancer: a tissue microarray study. . Hum. Pathol. . 34 . 2 . 143–9 . 2003 . 12612882 . 10.1053/hupa.2003.26 . etal.
• Dong Q, Kirley S, Rueda B . Loss of cables, a novel gene on chromosome 18q, in ovarian cancer. . Mod. Pathol. . 16 . 9 . 863–8 . 2004 . 13679449 . 10.1097/01.MP.0000084434.88269.0A . etal. free .
• Matsuoka M, Sudo H, Tsuji K . ik3-2, a relative to ik3-1/Cables, is involved in both p53-mediated and p53-independent apoptotic pathways. . Biochem. Biophys. Res. Commun. . 312 . 2 . 520–9 . 2004 . 14637168 . 10.1016/j.bbrc.2003.10.142 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Zukerberg LR, DeBernardo RL, Kirley SD . Loss of cables, a cyclin-dependent kinase regulatory protein, is associated with the development of endometrial hyperplasia and endometrial cancer. . Cancer Res. . 64 . 1 . 202–8 . 2004 . 14729625 . 10.1158/0008-5472.CAN-03-2833 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Zhang H, Duan HO, Kirley SD . Aberrant splicing of cables gene, a CDK regulator, in human cancers. . Cancer Biol. Ther. . 4 . 11 . 1211–5 . 2006 . 16177568 . 10.4161/cbt.4.11.2085. etal. 11303727 .
• Nusbaum C, Zody MC, Borowsky ML . DNA sequence and analysis of human chromosome 18. . Nature . 437 . 7058 . 551–5 . 2005 . 16177791 . 10.1038/nature03983 . etal. free . 2005Natur.437..551N .
• Beausoleil SA, Villén J, Gerber SA . A probability-based approach for high-throughput protein phosphorylation analysis and site localization. . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 . etal.
• Hirao N, Sato S, Gotoh T . NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation. . FEBS Lett. . 580 . 27 . 6464–70 . 2007 . 17101133 . 10.1016/j.febslet.2006.10.065 . 20005197 . etal. free .

Notes and References

1. Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc Natl Acad Sci U S A . 99 . 26 . 16899–903 . Dec 2002 . 12477932 . 139241 . 10.1073/pnas.242603899 . 2002PNAS...9916899M . free .
2. Web site: Entrez Gene: CABLES1 Cdk5 and Abl enzyme substrate 1.