Carbonic anhydrase 7 explained

Carbonic anhydrase 7 (CA7) is an enzyme that in humans is encoded by the CA7 gene.^{[1] [2]}

Function

Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. The cytosolic protein encoded by this gene is predominantly expressed in the salivary glands. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms.

Further reading

• Sly WS, Hu PY . Human carbonic anhydrases and carbonic anhydrase deficiencies . Annual Review of Biochemistry . 64 . 375–401 . 1995 . 7574487 . 10.1146/annurev.bi.64.070195.002111 .
• Rivera C, Voipio J, Kaila K . Two developmental switches in GABAergic signalling: the K+-Cl- cotransporter KCC2 and carbonic anhydrase CAVII . The Journal of Physiology . 562 . Pt 1 . 27–36 . Jan 2005 . 15528236 . 1665491 . 10.1113/jphysiol.2004.077495 .
• Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD . Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q . Genomics . 60 . 3 . 295–308 . Sep 1999 . 10493829 . 10.1006/geno.1999.5927 .
• Chagnon P, Michaud J, Mitchell G, Mercier J, Marion JF, Drouin E, Rasquin-Weber A, Hudson TJ, Richter A . A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis . American Journal of Human Genetics . 71 . 6 . 1443–9 . Dec 2002 . 12417987 . 378590 . 10.1086/344580 .
• Vullo D, Voipio J, Innocenti A, Rivera C, Ranki H, Scozzafava A, Kaila K, Supuran CT . Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides . Bioorganic & Medicinal Chemistry Letters . 15 . 4 . 971–6 . Feb 2005 . 15686895 . 10.1016/j.bmcl.2004.12.052 .

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Carbonic anhydrase 7

Notes and References

1. Montgomery JC, Venta PJ, Eddy RL, Fukushima YS, Shows TB, Tashian RE . Characterization of the human gene for a newly discovered carbonic anhydrase, CA VII, and its localization to chromosome 16 . Genomics . 11 . 4 . 835–48 . Dec 1991 . 1783392 . 10.1016/0888-7543(91)90006-Z . 2027.42/29017 . free .
2. Web site: Entrez Gene: CA7 carbonic anhydrase VII.