Complement component 6 explained

Complement component 6 is a protein that in humans is encoded by the C6 gene.^[1]

Complement component 6 is a protein involved in the complement system. It is part of the membrane attack complex which can insert into the cell membrane and cause the cell to lyse.

People with C6 deficiency are prone to bacterial infection.^[1]

Further reading

• Davila S, Froeling FE, Tan A . New genetic associations detected in a host response study to hepatitis B vaccine. . Genes Immun. . 11 . 3 . 232–8 . 2010 . 20237496 . 10.1038/gene.2010.1 . etal. free .
• Rajaraman P, Brenner AV, Butler MA . Common variation in genes related to innate immunity and risk of adult glioma. . Cancer Epidemiol. Biomarkers Prev. . 18 . 5 . 1651–8 . 2009 . 19423540 . 10.1158/1055-9965.EPI-08-1041 . 2771723. etal.
• Cerhan JR, Novak AJ, Fredericksen ZS . Risk of non-Hodgkin lymphoma in association with germline variation in complement genes. . Br. J. Haematol. . 145 . 5 . 614–23 . 2009 . 19344414 . 10.1111/j.1365-2141.2009.07675.x . 2820509. etal.
• Han S, Lan Q, Park AK . Polymorphisms in innate immunity genes and risk of childhood leukemia. . Hum. Immunol. . 71 . 7 . 727–30 . 2010 . 20438785 . 10.1016/j.humimm.2010.04.004 . 2967770. etal.
• Liu T, Qian WJ, Gritsenko MA . Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. . J. Proteome Res. . 4 . 6 . 2070–80 . 2005. 16335952 . 10.1021/pr0502065 . 1850943. etal.
• Kimura K, Wakamatsu A, Suzuki Y . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129. etal.
• Talmud PJ, Drenos F, Shah S . Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. . Am. J. Hum. Genet. . 85 . 5 . 628–42 . 2009 . 19913121 . 10.1016/j.ajhg.2009.10.014 . 2775832. etal.
• Müller-Eberhard HJ . Molecular organization and function of the complement system. . Annu. Rev. Biochem. . 57 . 321–47 . 1988 . 3052276 . 10.1146/annurev.bi.57.070188.001541 .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928. etal.
• Eid NA, Hussein AA, Elzein AM . Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring. . Malar. J. . 9 . 119 . 2010 . 20459687 . 10.1186/1475-2875-9-119 . 2877684. etal . free .
• Fosbrink M, Cudrici C, Tegla CA . Response gene to complement 32 is required for C5b-9 induced cell cycle activation in endothelial cells. . Exp. Mol. Pathol. . 86 . 2 . 87–94 . 2009 . 19162005 . 10.1016/j.yexmp.2008.12.005 . 2699899. etal.
• Rajaraman P, Brenner AV, Neta G . Risk of meningioma and common variation in genes related to innate immunity. . Cancer Epidemiol. Biomarkers Prev. . 19 . 5 . 1356–61 . 2010 . 20406964 . 10.1158/1055-9965.EPI-09-1151 . 3169167. etal.
• Ennis S, Jomary C, Mullins R . Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study. . Lancet . 372 . 9652 . 1828–34 . 2008 . 18842294 . 10.1016/S0140-6736(08)61348-3 . etal. 5983350 .
• Soejima M, Tachida H, Tsuneoka M . Nucleotide sequence analyses of human complement 6 (C6) gene suggest balancing selection. . Ann. Hum. Genet. . 69 . Pt 3 . 239–52 . 2005 . 15845028 . 10.1046/j.1529-8817.2005.00165.x . etal.
• Bulla R, Bossi F, Agostinis C . Complement production by trophoblast cells at the feto-maternal interface. . J. Reprod. Immunol. . 82 . 2 . 119–25 . 2009 . 19665237 . 10.1016/j.jri.2009.06.124 . etal.
• Gancz D, Donin N, Fishelson Z . Involvement of the c-jun N-terminal kinases JNK1 and JNK2 in complement-mediated cell death. . Mol. Immunol. . 47 . 2–3 . 310–7 . 2009 . 19864026 . 10.1016/j.molimm.2009.09.016 . free .
• Parham KL, Roberts A, Thomas A . Prevalence of mutations leading to complete C6 deficiency (C6Q0) in the Western Cape, South Africa and detection of novel mutations leading to C6Q0 in an Irish family. . Mol. Immunol. . 44 . 10 . 2756–60 . 2007 . 17257682 . 10.1016/j.molimm.2006.11.022 . etal.
• Wu C, Ma MH, Brown KR . Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. . Proteomics . 7 . 11 . 1775–85 . 2007 . 17474147 . 10.1002/pmic.200601006 . 22474278 . etal.
• Bailey SD, Xie C, Do R . Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. . Diabetes Care . 33 . 10 . 2250–3 . 2010 . 20628086 . 10.2337/dc10-0452 . 2945168. etal.

Notes and References

1. Web site: Entrez Gene: complement component 6 C6 complement C6 (Homo sapiens (human)) Gene ID: 729 . 24 November 2020. 9 December 2020 . www.ncbi.nlm.nih.gov .