C1orf38 Explained

Chromosome 1 open reading frame 38 is a protein that in humans is encoded by the C1orf38 gene.^[1] The gene is also known as ICB-1 and THEMIS2 in humans, and the orthologue in mice is BC013712.^[1] C1orf38 has been associated with cancer susceptibility.^[2]

Further reading

• Haselberger M, Springwald A, Konwisorz A, Lattrich C, Goerse R, Ortmann O, Treeck O . Silencing of the icb-1 gene inhibits the induction of differentiation-associated genes by vitamin D3 and all-trans retinoic acid in gynecological cancer cells . International Journal of Molecular Medicine . 28 . 1 . 121–127 . July 2011 . 21455565 . 10.3892/ijmm.2011.663 . free .
• Springwald A, Lattrich C, Skrzypczak M, Goerse R, Ortmann O, Treeck O . Icb-1 Gene expression is elevated in human endometrial adenocarcinoma and is closely associated with HER2 expression . Cancer Investigation . 28 . 9 . 904–909 . November 2010 . 20569072 . 10.3109/07357907.2010.483511 . 35017943 .
• Konwisorz A, Springwald A, Haselberger M, Goerse R, Ortmann O, Treeck O . Knockdown of ICB-1 gene enhanced estrogen responsiveness of ovarian and breast cancer cells . Endocrine-Related Cancer . 17 . 1 . 147–157 . March 2010 . 19942713 . 10.1677/ERC-09-0095 . free .

Notes and References

1. Web site: Chromosome 1 open reading frame 38. 2011-12-07.
2. Springwald A, Lattrich C, Seitz S, Ortmann O, Treeck O . Single nucleotide polymorphisms in human gene icb-1 and breast cancer susceptibility . Cancer Investigation . 27 . 6 . 669–672 . July 2009 . 19308812 . 10.1080/07357900802620877 . 205570175 .