Chromosome 19 open reading frame 33 explained

Chromosome 19 open reading frame 33 is a protein that in humans is encoded by the C19orf33 gene.^[1]

Function

The protein encoded by this gene has been shown to be upregulated in SV40-immortalized fibroblasts as well as in endometrial carcinoma cells. The encoded protein is found primarily in the nucleus. This protein may play a role in placental development and diseases such as pre-eclampsia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015].

Further reading

• Itoh H, Kataoka H, Yamauchi M, Naganuma S, Akiyama Y, Nuki Y, Shimomura T, Miyazawa K, Kitamura N, Koono M . Identification of hepatocyte growth factor activator inhibitor type 2 (HAI-2)-related small peptide (H2RSP): its nuclear localization and generation of chimeric mRNA transcribed from both HAI-2 and H2RSP genes . Biochem. Biophys. Res. Commun. . 288 . 2 . 390–9 . October 2001 . 11606055 . 10.1006/bbrc.2001.5767 .
• Kim JK, An HJ, Kim NK, Ahn JY, Kim KS, Kang YJ, Ko JJ, Oh D, Lee C, Kim SJ, Cha KY . IMUP-1 and IMUP-2 genes are up-regulated in human ovarian epithelial tumors . Anticancer Res. . 23 . 6C . 4709–13 . 2003 . 14981917 .
• Naganuma S, Itoh H, Uchiyama S, Nagaike K, Tanaka H, Akiyama Y, Chijiiwa K, Kataoka H . Nuclear translocation of H2RSP is impaired in regenerating intestinal epithelial cells of murine colitis model . Virchows Arch. . 448 . 3 . 354–60 . March 2006 . 16189703 . 10.1007/s00428-005-0064-6 . 1817907 .
• Betsunoh H, Mukai S, Akiyama Y, Fukushima T, Minamiguchi N, Hasui Y, Osada Y, Kataoka H . Clinical relevance of hepsin and hepatocyte growth factor activator inhibitor type 2 expression in renal cell carcinoma . Cancer Sci. . 98 . 4 . 491–8 . April 2007 . 17309599 . 10.1111/j.1349-7006.2007.00412.x . 26220332 . 11160002 .
• Kim SJ, An HJ, Kim HJ, Jungs HM, Lee S, Ko JJ, Kim IH, Sakuragi N, Kim JK . Imup-1 and imup-2 overexpression in endometrial carcinoma in Korean and Japanese populations . Anticancer Res. . 28 . 2A . 865–71 . 2008 . 18507030 .
• Jeon SY, Lee HJ, Park JM, Jung HM, Yoo JK, Lee HJ, Lee JS, Cha DH, Kim JK, Kim GJ . Increased immortalization-upregulated protein 2 (IMUP-2) by hypoxia induces apoptosis of the trophoblast and pre-eclampsia . J. Cell. Biochem. . 110 . 2 . 522–30 . May 2010 . 20432246 . 10.1002/jcb.22568 . 42000298 .

Notes and References

1. Web site: Entrez Gene: Chromosome 19 open reading frame 33. 2018-10-23.