URI1 explained

Unconventional prefoldin RPB5 interactor, also called URI1, is a protein that in humans is encoded by the URI1 gene.^{[1] [2] [3]}

Function

The protein encoded by this gene binds to RNA polymerase II subunit 5 (RPB5) and negatively modulates transcription through its binding to RPB5. The encoded protein seems to have inhibitory effects on various types of activated transcription, but it requires the RPB5-binding region. This protein acts as a corepressor. It is suggested that it may require signaling processes for its function or that it negatively modulates genes in the chromatin structure. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Interactions

URI1 has been shown to interact with DMAP1^[4] and STAP1.^[5]

External links

Further reading

• Liu L, McKeehan WL . Sequence analysis of LRPPRC and its SEC1 domain interaction partners suggests roles in cytoskeletal organization, vesicular trafficking, nucleocytosolic shuttling, and chromosome activity . Genomics . 79 . 1 . 124–36 . 2002 . 11827465 . 3241999 . 10.1006/geno.2001.6679 .
• Wei W, Gu JX, Zhu CQ, Sun FY, Dorjsuren D, Lin Y, Murakami S . Interaction with general transcription factor IIF (TFIIF) is required for the suppression of activated transcription by RPB5-mediating protein (RMP) . Cell Res. . 13 . 2 . 111–20 . 2003 . 12737519 . 10.1038/sj.cr.7290155 . free .
• Gstaiger M, Luke B, Hess D, Oakeley EJ, Wirbelauer C, Blondel M, Vigneron M, Peter M, Krek W . Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI . Science . 302 . 5648 . 1208–12 . 2003 . 14615539 . 10.1126/science.1088401 . 2003Sci...302.1208G . 26836888 .
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G . A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway . Nat. Cell Biol. . 6 . 2 . 97–105 . 2004 . 14743216 . 10.1038/ncb1086 . 11683986 .
• Delgermaa L, Hayashi N, Dorjsuren D, Nomura T, Thuy le TT, Murakami S . Subcellular Localization of RPB5-Mediating Protein and Its Putative Functional Partner . Mol. Cell. Biol. . 24 . 19 . 8556–66 . 2004 . 15367675 . 516735 . 10.1128/MCB.24.19.8556-8566.2004 .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .

Notes and References

1. Van Leuven F, Torrekens S, Moechars D, Hilliker C, Buellens M, Bollen M, Delabie J . Molecular cloning of a gene on chromosome 19q12 coding for a novel intracellular protein: analysis of expression in human and mouse tissues and in human tumor cells, particularly Reed-Sternberg cells in Hodgkin disease . Genomics . 54 . 3 . 511–20 . Feb 1999 . 9878255 . 10.1006/geno.1998.5609 .
2. Dorjsuren D, Lin Y, Wei W, Yamashita T, Nomura T, Hayashi N, Murakami S . RMP, a Novel RNA Polymerase II Subunit 5-Interacting Protein, Counteracts Transactivation by Hepatitis B Virus X Protein . Mol Cell Biol . 18 . 12 . 7546–55 . Dec 1998 . 9819440 . 109335 . 10.1128/mcb.18.12.7546.
3. Web site: Entrez Gene: C19orf2 chromosome 19 open reading frame 2.
4. Delgermaa L, Hayashi N, Dorjsuren D, Nomura T, Thuy le TT, Murakami S . Subcellular Localization of RPB5-Mediating Protein and Its Putative Functional Partner . Mol. Cell. Biol. . 24 . 19 . 8556–66 . Oct 2004 . 15367675 . 516735 . 10.1128/MCB.24.19.8556-8566.2004 . 10.1.1.605.6435 .
5. Gstaiger M, Luke B, Hess D, Oakeley EJ, Wirbelauer C, Blondel M, Vigneron M, Peter M, Krek W . Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI . . 302 . 5648 . 1208–12 . Nov 2003 . 14615539 . 10.1126/science.1088401 . 2003Sci...302.1208G . 26836888 .