C11orf53 Explained

Chromosome 11 open reading frame 53 is a protein that in humans is encoded by the C11orf53 gene.[1] Reduction in C11orf53 gene expression is associated with increased odds of occurrence of colorectal cancer.[2] Specifically sequence variation (rs3802842) close to the C11orf53 gene locus that lowers the expression of C11orf53 has been observed in the colonic mucosal cells immediately adjacent to colon cancer tumors.[3] [4] C11orf53 downregulation aids in cells' ability to survive in acidic conditions, which are typical of the tumor microenvironment.[5] CRISPR-Cas9 inactivation of C11orf53 in an acute myeloid leukemia cell line made the cells resistant to the BCL2 inhibitor Venetoclax, further supporting a role in cancer predisposition.[6] [7]

Additional roles have been proposed.[8] [9]

Notes and References

  1. Web site: C11orf53 chromosome 11 open reading frame 53 [Homo sapiens (human)] - Gene - NCBI ]. www.ncbi.nlm.nih.gov.
  2. Delgado AP, Brandao P, Chapado MJ, Hamid S, Narayanan R . Open reading frames associated with cancer in the dark matter of the human genome . Cancer Genomics & Proteomics . 11 . 4 . 201–213 . July 2014 . 25048349 .
  3. Biancolella M, Fortini BK, Tring S, Plummer SJ, Mendoza-Fandino GA, Hartiala J, Hitchler MJ, Yan C, Schumacher FR, Conti DV, Edlund CK, Noushmehr H, Coetzee SG, Bresalier RS, Ahnen DJ, Barry EL, Berman BP, Rice JC, Coetzee GA, Casey G . 6 . Identification and characterization of functional risk variants for colorectal cancer mapping to chromosome 11q23.1 . Human Molecular Genetics . 23 . 8 . 2198–2209 . April 2014 . 24256810 . 3959808 . 10.1093/hmg/ddt584 .
  4. Closa A, Cordero D, Sanz-Pamplona R, Solé X, Crous-Bou M, Paré-Brunet L, Berenguer A, Guino E, Lopez-Doriga A, Guardiola J, Biondo S, Salazar R, Moreno V . 6 . Identification of candidate susceptibility genes for colorectal cancer through eQTL analysis . Carcinogenesis . 35 . 9 . 2039–2046 . September 2014 . 24760461 . 4146415 . 10.1093/carcin/bgu092 .
  5. Funato Y, Yoshida A, Hirata Y, Hashizume O, Yamazaki D, Miki H . The Oncogenic PRL Protein Causes Acid Addiction of Cells by Stimulating Lysosomal Exocytosis . Developmental Cell . 55 . 4 . 387–397.e8 . November 2020 . 32918875 . 10.1016/j.devcel.2020.08.009 . 221643438 . free .
  6. Web site: C11orf53 CRISPR Screens (Homo sapiens) . orcs.thebiogrid.org.
  7. Nechiporuk T, Kurtz SE, Nikolova O, Liu T, Jones CL, D'Alessandro A, Culp-Hill R, d'Almeida A, Joshi SK, Rosenberg M, Tognon CE, Danilov AV, Druker BJ, Chang BH, McWeeney SK, Tyner JW . 6 . The TP53 Apoptotic Network Is a Primary Mediator of Resistance to BCL2 Inhibition in AML Cells . Cancer Discovery . 9 . 7 . 910–925 . July 2019 . 31048320 . 6606338 . 10.1158/2159-8290.CD-19-0125 .
  8. Web site: C11orf53 chromosome 11 open reading frame 53 [Homo sapiens (human)] - Gene - NCBI ]. www.ncbi.nlm.nih.gov.
  9. Oláh J, Vincze O, Virók D, Simon D, Bozsó Z, Tõkési N, Horváth I, Hlavanda E, Kovács J, Magyar A, Szũcs M, Orosz F, Penke B, Ovádi J . 6 . Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein . The Journal of Biological Chemistry . 286 . 39 . 34088–34100 . September 2011 . 21832049 . 3190826 . 10.1074/jbc.M111.243907 . free .

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