EMSY explained

EMSY is a protein that in humans is encoded by the EMSY gene.^[1]

Clinical significance

EMSY has been shown to associate with atopy and susceptibility to poly-sensitisation.^[2]

Interactions

EMSY has been shown to interact with ZMYND11,^[3] BRCA2^[3] and CBX1.^[3]

Further reading

• Hughes-Davies L, Huntsman D, Ruas M, Fuks F, Bye J, Chin SF, Milner J, Brown LA, Hsu F, Gilks B, Nielsen T, Schulzer M, Chia S, Ragaz J, Cahn A, Linger L, Ozdag H, Cattaneo E, Jordanova ES, Schuuring E, Yu DS, Venkitaraman A, Ponder B, Doherty A, Aparicio S, Bentley D, Theillet C, Ponting CP, Caldas C, Kouzarides T . EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer . Cell . 115 . 5 . 523–35 . 2003 . 14651845 . 10.1016/S0092-8674(03)00930-9 . 18911371 . free .
• Bera TK, Das S, Maeda H, Beers R, Wolfgang CD, Kumar V, Hahn Y, Lee B, Pastan I . NGEP, a gene encoding a membrane protein detected only in prostate cancer and normal prostate . Proc. Natl. Acad. Sci. U.S.A. . 101 . 9 . 3059–64 . 2004 . 14981236 . 365744 . 10.1073/pnas.0308746101 . 2004PNAS..101.3059B . free .
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .
• Ekblad CM, Chavali GB, Basu BP, Freund SM, Veprintsev D, Hughes-Davies L, Kouzarides T, Doherty AJ, Itzhaki LS . Binding of EMSY to HP1beta: implications for recruitment of HP1beta and BS69 . EMBO Rep. . 6 . 7 . 675–80 . 2005 . 15947784 . 1369107 . 10.1038/sj.embor.7400415 .
• Chavali GB, Ekblad CM, Basu BP, Brissett NC, Veprintsev D, Hughes-Davies L, Kouzarides T, Itzhaki LS, Doherty AJ . Crystal structure of the ENT domain of human EMSY . J. Mol. Biol. . 350 . 5 . 964–73 . 2005 . 15978617 . 10.1016/j.jmb.2005.05.047 .
• Benusiglio PR, Lesueur F, Luccarini C, McIntosh J, Luben RN, Smith P, Dunning A, Easton DF, Ponder BA, Pharoah PD . Common variation in EMSY and risk of breast and ovarian cancer: a case-control study using HapMap tagging SNPs . BMC Cancer . 5 . 81 . 2005 . 16029503 . 1185523 . 10.1186/1471-2407-5-81 . free .
• Raouf A, Brown L, Vrcelj N, To K, Kwok W, Huntsman D, Eaves CJ . Genomic instability of human mammary epithelial cells overexpressing a truncated form of EMSY . J. Natl. Cancer Inst. . 97 . 17 . 1302–6 . 2005 . 16145051 . 10.1093/jnci/dji254 . free .
• Brown LA, Irving J, Parker R, Kim H, Press JZ, Longacre TA, Chia S, Magliocco A, Makretsov N, Gilks B, Pollack J, Huntsman D . Amplification of EMSY, a novel oncogene on 11q13, in high grade ovarian surface epithelial carcinomas . Gynecol. Oncol. . 100 . 2 . 264–70 . 2006 . 16236351 . 10.1016/j.ygyno.2005.08.026 .
• Huang Y, Myers MP, Xu RM . Crystal structure of the HP1-EMSY complex reveals an unusual mode of HP1 binding . Structure . 14 . 4 . 703–12 . 2006 . 16615912 . 10.1016/j.str.2006.01.007 . free .

Notes and References

1. Web site: Entrez Gene: C11orf30 chromosome 11 open reading frame 30.
2. Amaral. A. F. S.. Minelli. C.. Guerra. S.. Wjst. M.. Probst-Hensch. N.. Pin. I.. Svanes. C.. Janson. C.. Heinrich. J.. Jarvis. D. L.. The locus C11orf30 increases susceptibility to poly-sensitization. Allergy. March 2015. 70. 3. 328–333. 10.1111/all.12557. 25546184. 10044/1/21574. 25960081. free.
3. Hughes-Davies L, Huntsman D, Ruas M, Fuks F, Bye J, Chin SF, Milner J, Brown LA, Hsu F, Gilks B, Nielsen T, Schulzer M, Chia S, Ragaz J, Cahn A, Linger L, Ozdag H, Cattaneo E, Jordanova ES, Schuuring E, Yu DS, Venkitaraman A, Ponder B, Doherty A, Aparicio S, Bentley D, Theillet C, Ponting CP, Caldas C, Kouzarides T . EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer . Cell . 115 . 5 . 523–35 . Nov 2003 . 14651845 . 10.1016/S0092-8674(03)00930-9 . 18911371 . free .