Gene C11orf16, chromosome 11 open reading frame 16, is a protein in humans that is encoded by the C11orf16 gene.[1] [2] It has 7 exons, and the size of 467 amino acids.
The gene C11orf16 is located on chromosome 11(p15.4), starting at 8,920,076bp and ending at 8,933,006bp.
Gene ASCL3 and AKIP1 are the neighbor genes of C11orf16 on chromosome 11.
The gene does not have high expression throughout the body tissues. The percentile rank within the sample are higher in pancreas, ovary, and appendix.
Even though the gene does not have a significant high expression in the mouse brain, it is most expressed in midbrain, isocortex, olfactory areas, and medulla.
Some transcription factors that have the higher matrix similarity are Kruppel-like zinc finger protein 219, zinc finger protein 263, ZKSCAN12 (zinc finger protein with KRAB and SCAN domains 12), chorion-specific transcription factor GCMa, and Ras-responsive element binding protein 1.[3]
The predicted C11orf16 transcript variant X1 is 2386bp long and has NCBI accession number of XM_017018013.1.[4]
No paralogs were found for the C11orf16 gene through NCBI BLAST.
| Description | Common name | NCBI accession ID | Query cover | E value | Identity | Date of divergence (MYA) | |
|---|---|---|---|---|---|---|---|
| Homo sapiens | Human | NP_065694.2 | 100 % | 0 | 100% | N/A | |
| Pongo abelii | Sumatran orangutan | PNJ24628 | 84% | 0 | 95% | 15.2 | |
| Aotus nancymaae | Nancy Ma's night monkey | XP_012312127.1 | 88% | 0 | 84% | 42.6 | |
| Chinchilla lanigera | Long-tailed chinchilla | XP_013367496.1 | 97% | 0 | 68% | 88 | |
| Equus przewalskii | Przewalski's horse | XP_008512245.1 | 98% | 0 | 73% | 94 | |
| Cervus elaphus hippelaphus | Central European red deer | OWK17675.1 | 99% | 0 | 67% | 94 | |
| Hipposideros armiger | Great roundleaf bat | XP_019511755.1 | 99% | 0 | 65% | 94 | |
| Neomonachus schauinslandi | Hawaiian monk seal | XP_021541375.1 | 99% | 0 | 66% | 94 | |
| Lipotes vexillifer | Baiji | XP_007459933.1 | 98% | 0 | 68% | 94 | |
| Myotis brandtii | Brandt's bat | XP_005874017.1 | 98% | 1e-174 | 67% | 94 | |
| Chelonia mydas | Green sea turtle | XP_007057171.1 | 83% | 1e-57 | 37% | 320 | |
| Balearica regulorum gibbericeps | Grey crowned crane | XP_010311948.1 | 70% | 6e-5 | 40% | 320 |
The gene C11orf16 is conserved in many animal species including mammals, avians, and reptiles.
The predicted molecular weight of the protein encoded by C11orf16 is 51 kilodaltons.[5] [6]
Several protein domains and motifs were found including CHD5-like protein, tyrosine kinase phosphorylation site, protein kinase C phosphorylation site, N-myristoylation site, casein kinase II phosphorylation site, and cGMP-dependent protein kinase phosphorylation site.[7] The picture indicates the location of the motifs.
The protein is predicted to be made up with 21.2% of alpha helix, 15.2% of extended strand, and 63% of random coil.
No transmembrane helices,[8] potential GPI-modification sites, or TM-proteins were found. There were seven predicted sumoylation sites,[9] multiple phosporylation sites with most of them being unspecified, and nine glycosylation sites.[10]
The protein is predicted to be localized to the nucleus with the probability of 47.8%; mitochondria with the probability of 26.1%.[11]
Proteins C1orf105 (Chromosome 1 open reading frame 105), PWWP2A, and SMYD1(SET and MYND domain containing 1) were found to be interacting with C11orf16.[12]
Protein coded by C11orf16 gene is also predicted to have 19.61% sequence identity to tumor suppressor p53-binding protein suggesting that this gene might be involved with tumor suppressing process.[13]
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