CFLAR explained

CASP8 and FADD-like apoptosis regulator is a protein that in humans is encoded by the CFLAR gene.^{[1] [2]} Also called c-FLIP (FLICE-like inhibitory protein).

Further reading

• Abe K, Kurakin A, Mohseni-Maybodi M . The complexity of TNF-related apoptosis-inducing ligand. . Ann. N. Y. Acad. Sci. . 926 . 1. 52–63 . 2001 . 11193041 . 10.1111/j.1749-6632.2000.tb05598.x . 45991330 . etal.
• Dutton A, Young LS, Murray PG . The role of cellular FLICE inhibitory protein (c-FLIP) in the pathogenesis and treatment of cancer. . Expert Opin. Ther. Targets . 10 . 1 . 27–35 . 2006 . 16441226 . 10.1517/14728222.10.1.27 . 45292123 .

Notes and References

1. Shu HB, Halpin DR, Goeddel DV . Casper is a FADD- and caspase-related inducer of apoptosis . Immunity . 6 . 6 . 751–63 . Jul 1997 . 9208847 . 10.1016/S1074-7613(00)80450-1 . free .
2. Irmler M, Thome M, Hahne M, Schneider P, Hofmann K, Steiner V, Bodmer JL, Schroter M, Burns K, Mattmann C, Rimoldi D, French LE, Tschopp J . Inhibition of death receptor signals by cellular FLIP . Nature . 388 . 6638 . 190–5 . Jul 1997 . 9217161 . 10.1038/40657 . 4341495 . free .