C-C motif chemokine ligand 24 explained

C-C motif chemokine ligand 24 is a protein that in humans is encoded by the CCL24 gene.^[1]

Function

This gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity on resting T lymphocytes, a minimal activity on neutrophils, and is negative on monocytes and activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. [provided by RefSeq, Jul 2008].

Further reading

• Papadopoulos NG, Papi A, Meyer J, Stanciu LA, Salvi S, Holgate ST, Johnston SL . Rhinovirus infection up-regulates eotaxin and eotaxin-2 expression in bronchial epithelial cells . Clin. Exp. Allergy . 31 . 7 . 1060–6 . July 2001 . 11467997 . 10.1046/j.1365-2222.2001.01112.x. 20581201 .
• Tachimoto H, Kikuchi M, Hudson SA, Bickel CA, Hamilton RG, Bochner BS . Eotaxin-2 alters eosinophil integrin function via mitogen-activated protein kinases . Am. J. Respir. Cell Mol. Biol. . 26 . 6 . 645–9 . June 2002 . 12034562 . 10.1165/ajrcmb.26.6.4741 .
• Badewa AP, Hudson CE, Heiman AS . Regulatory effects of eotaxin, eotaxin-2, and eotaxin-3 on eosinophil degranulation and superoxide anion generation . Exp. Biol. Med. (Maywood) . 227 . 8 . 645–51 . September 2002 . 12192108 . 10.1177/153537020222700814. 32212646 .
• Menzies-Gow A, Ying S, Sabroe I, Stubbs VL, Soler D, Williams TJ, Kay AB . Eotaxin (CCL11) and eotaxin-2 (CCL24) induce recruitment of eosinophils, basophils, neutrophils, and macrophages as well as features of early- and late-phase allergic reactions following cutaneous injection in human atopic and nonatopic volunteers . J. Immunol. . 169 . 5 . 2712–8 . September 2002 . 12193745 . 10.4049/jimmunol.169.5.2712. free .
• Chae SC, Lee YC, Park YR, Shin JS, Song JH, Oh GJ, Hong ST, Pae HO, Choi BM, Chung HT . Analysis of the polymorphisms in eotaxin gene family and their association with asthma, IgE, and eosinophil . Biochem. Biophys. Res. Commun. . 320 . 1 . 131–7 . July 2004 . 15207712 . 10.1016/j.bbrc.2004.05.136 .
• Chae SC, Park YR, Oh GJ, Lee JH, Chung HT . The suggestive association of eotaxin-2 and eotaxin-3 gene polymorphisms in Korean population with allergic rhinitis . Immunogenetics . 56 . 10 . 760–4 . January 2005 . 15580493 . 10.1007/s00251-004-0746-2 . 45416407 .
• Min JW, Lee JH, Park CS, Chang HS, Rhim TY, Park SW, Jang AS, Shin HD . Association of eotaxin-2 gene polymorphisms with plasma eotaxin-2 concentration . J. Hum. Genet. . 50 . 3 . 118–23 . 2005 . 15744457 . 10.1007/s10038-005-0230-3 . free .
• Min JW, Jang AS, Park SM, Lee SH, Lee JH, Park SW, Park CS . Comparison of plasma eotaxin family level in aspirin-induced and aspirin-tolerant asthma patients . Chest . 128 . 5 . 3127–32 . November 2005 . 16304252 . 10.1378/chest.128.5.3127 .
• Park YR, Choi SC, Lee ST, Kim KS, Chae SC, Chung HT . The association of eotaxin-2 and eotaxin-3 gene polymorphisms in a Korean population with ulcerative colitis . Exp. Mol. Med. . 37 . 6 . 553–8 . December 2005 . 16391516 . 10.1038/emm.2005.68 . free .

Notes and References

1. Web site: Entrez Gene: C-C motif chemokine ligand 24. 2018-05-09.