Bxd (gene) explained

Bithoraxoid conserved region 1
Symbol:	bxd_1
Rfam:	RF01929
Rna Type:	Gene
Tax Domain:	Drosophila

Bithoraxoid (bxd) is a long non-coding RNA found in Drosophila. It silences the expression of the Ultrabithorax (Ubx) gene by transcriptional interference.^{[1] [2]}

Further reading

• Janssen R, Budd GE . Gene expression suggests conserved aspects of Hox gene regulation in arthropods and provides additional support for monophyletic Myriapoda . Evodevo . 1 . 1 . 4 . 2010 . 20849647 . 2938723 . 10.1186/2041-9139-1-4 . free .
• Kozma G, Bender W, Sipos L . Replacement of a Drosophila Polycomb response element core, and in situ analysis of its DNA motifs . Mol. Genet. Genomics . 279 . 6 . 595–603 . June 2008 . 18350319 . 10.1007/s00438-008-0336-3 . 22013486 .
• Faucheux M, Roignant JY, Netter S, Charollais J, Antoniewski C, Théodore L . batman Interacts with polycomb and trithorax group genes and encodes a BTB/POZ protein that is included in a complex containing GAGA factor . Mol. Cell. Biol. . 23 . 4 . 1181–1195 . February 2003 . 12556479 . 141128 . 10.1128/mcb.23.4.1181-1195.2003.
• Huang DH, Chang YL, Yang CC, Pan IC, King B . pipsqueak encodes a factor essential for sequence-specific targeting of a polycomb group protein complex . Mol. Cell. Biol. . 22 . 17 . 6261–6271 . September 2002 . 12167718 . 134006 . 10.1128/mcb.22.17.6261-6271.2002.
• Rivlin PK, Gong A, Schneiderman AM, Booker R . The role of Ultrabithorax in the patterning of adult thoracic muscles in Drosophila melanogaster . Dev. Genes Evol. . 211 . 2 . 55–66 . February 2001 . 11455415 . 10.1007/s004270000126. 25484062 .
• Hodgson JW, Argiropoulos B, Brock HW . Site-specific recognition of a 70-base-pair element containing d(GA)(n) repeats mediates bithoraxoid polycomb group response element-dependent silencing . Mol. Cell. Biol. . 21 . 14 . 4528–4543 . July 2001 . 11416132 . 87112 . 10.1128/MCB.21.14.4528-4543.2001 .

Notes and References

1. Petruk S, Sedkov Y, Riley KM . Transcription of bxd noncoding RNAs promoted by trithorax represses Ubx in cis by transcriptional interference . Cell . 127 . 6 . 1209–1221 . December 2006 . 17174895 . 1866366 . 10.1016/j.cell.2006.10.039 . etal.
2. Petruk S, Sedkov Y, Brock HW, Mazo A . A model for initiation of mosaic HOX gene expression patterns by non-coding RNAs in early embryos . RNA Biol . 4 . 1 . 1–6 . 2007 . 17568198 . 10.4161/rna.4.1.4300. free .