Butyrophilin, subfamily 2, member A2 explained
Butyrophilin subfamily 2 member A2 is a protein that in humans is encoded by the BTN2A2 gene.[1] [2] [3]
Function
Butyrophilin is the major protein associated with fat droplets in the milk. This gene is a member of the BTN2 subfamily of genes, which encode proteins belonging to the butyrophilin protein family. The gene is located in a cluster on chromosome 6, consisting of seven genes belonging to the expanding B7/butyrophilin-like group, a subset of the immunoglobulin gene superfamily. The encoded protein is a type 1 receptor glycoprotein involved in lipid, fatty-acid and sterol metabolism. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.[3]
Further reading
- Cavaletto M, Giuffrida MG, Fortunato D, Gardano L, Dellavalle G, Napolitano L, Giunta C, Bertino E, Fabris C, Conti A . A proteomic approach to evaluate the butyrophilin gene family expression in human milk fat globule membrane . Proteomics . 2 . 7 . 850–6 . July 2002 . 12124930 . 10.1002/1615-9861(200207)2:7<850::AID-PROT850>3.0.CO;2-C . 25710334 .
- Rhodes DA, Stammers M, Malcherek G, Beck S, Trowsdale J . The cluster of BTN genes in the extended major histocompatibility complex . Genomics . 71 . 3 . 351–62 . February 2001 . 11170752 . 10.1006/geno.2000.6406 .
Notes and References
- Henry J, Miller MM, Pontarotti P . Structure and evolution of the extended B7 family . Immunology Today . 20 . 6 . 285–8 . June 1999 . 10354554 . 10.1016/S0167-5699(98)01418-2 .
- Ruddy DA, Kronmal GS, Lee VK, Mintier GA, Quintana L, Domingo R, Meyer NC, Irrinki A, McClelland EE, Fullan A, Mapa FA, Moore T, Thomas W, Loeb DB, Harmon C, Tsuchihashi Z, Wolff RK, Schatzman RC, Feder JN . A 1.1-Mb transcript map of the hereditary hemochromatosis locus . Genome Research . 7 . 5 . 441–56 . May 1997 . 9149941 . 10.1101/gr.7.5.441 . free .
- Web site: Entrez Gene: BTN2A2 butyrophilin, subfamily 2, member A2.
