Butidrine Explained

Width:	250px
Tradename:	Betabloc, Butidrate, Recetan
Class:	Beta blocker
Cas Number:	7433-10-5
Pubchem:	15177
Chemspiderid:	14445
Unii:	N2S0PKP5L5
Chebi:	135008
Chembl:	358930
Synonyms:	Butedrine; Butydrine; Hydrobutamine; Idrobutamine
Iupac Name:	2-(butan-2-ylamino)-1-(5,6,7,8-tetrahydronaphthalen-2-yl)ethanol
C:	16
H:	25
N:	1
O:	1
Smiles:	CCC(C)NCC(C1=CC2=C(CCCC2)C=C1)O
Stdinchi:	1S/C16H25NO/c1-3-12(2)17-11-16(18)15-9-8-13-6-4-5-7-14(13)10-15/h8-10,12,16-18H,3-7,11H2,1-2H3
Stdinchikey:	GVNYSERWAKVROD-UHFFFAOYSA-N

Butidrine, sold under the brand names Betabloc, Butidrate, and Recetan among others, is a beta blocker (or β-adrenergic receptor antagonist) related to pronethalol^[1] and propranolol^[2] that was developed in the 1960s.^{[3] [4]} It is not cardioselective (i.e., is not selective for the β₁-adrenergic receptor over the β₂-adrenergic receptor).^[5] It has membrane stabilizing activity but no intrinsic sympathomimetic activity (i.e., partial agonist activity).^[6] Similarly to certain other beta blockers, butidrine additionally possesses local anesthetic properties.^[7]

Notes and References

1. Book: Bristol JA . Cardiovascular drugs. 1986. John Wiley & Sons, Incorporated. 978-0-471-09228-5. 111.
2. Book: Drug Metabolism Reviews. 1972. Marcel Dekker.
3. Book: Morton IK, Hall JM . Concise Dictionary of Pharmacological Agents: Properties and Synonyms. 6 December 2012. Springer Science & Business Media. 978-94-011-4439-1. 58–.
4. Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 197–.
5. Sokabe . Hirofumi . A new classification of β-adrenoceptor blocking drugs . Trends in Pharmacological Sciences . 6 . 1985 . 10.1016/0165-6147(85)90051-3 . 107–109.
6. Fitzgerald JD . Perspectives in adrenergic beta-receptor blockade . Clin Pharmacol Ther . 10 . 3 . 292–306 . 1969 . 4894830 . 10.1002/cpt1969103292 .
7. Book: Charlier R . Antianginal drugs: pathophysiological, haemodynamic, methodological, pharmacological, biochemical and clinical basis for their use in human therapeutics. 1971. Springer-Verlag. 978-3-540-05365-1.