Butanilicaine Explained

Butanilicaine is a local anesthetic. It is also known by the name Hostacaine.

Synthesis

Amide formation by the combination of 2-chloro-6-methylaniline (1) and chloroacetyl chloride (2) gives the intermediate (3), which is used to alkylate N-butylamine (4) to yield butanilicaine.[1] [2] [3]

Notes and References

  1. Web site: Butanilicaine . Thieme . 2024-07-01 .
  2. 10.1021/ja01541a028 . N-(Substituted Aminoacyl)-chloroanilines . 1958 . Epstein . Elias . Kaminsky . Daniel . Journal of the American Chemical Society . 80 . 8 . 1892–1895 .
  3. 1957 to Hoechst AG.

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