| Buster Brown | |
| Position: | Pitcher |
| Birth Date: | 31 August 1881 |
| Birth Place: | Boone, Iowa, U.S. |
| Death Place: | Sioux City, Iowa, U.S. |
| Bats: | Right |
| Throws: | Right |
| Debutleague: | MLB |
| Debutdate: | June 22 |
| Debutyear: | 1905 |
| Debutteam: | St. Louis Cardinals |
| Finalleague: | MLB |
| Finaldate: | April 26 |
| Finalyear: | 1913 |
| Finalteam: | Boston Braves |
| Stat2label: | Earned run average |
| Stat2value: | 3.21 |
| Stat3label: | Strikeouts |
| Stat3value: | 501 |
| Statleague: | MLB |
| Stat1label: | Win–loss record |
| Stat1value: | 51–103 |
| Teams: | |
Charles Edward "Buster" Brown (August 31, 1881 – February 9, 1914) was an American Major League Baseball pitcher from to . He played for the Philadelphia Phillies, St. Louis Cardinals, and Boston Braves. He has the record for the lowest career winning percentage of any pitcher with a minimum of 150 decisions at .327 for a record of 51 wins and 105 losses. Brown died of blood poisoning following an operation to remove a growth under his right arm. He is buried in Onawa, Iowa.