Buspirone/testosterone explained

Buspirone/testosterone (tentative brand name Lybridos) is a combination of buspirone, a 5-HT_1A receptor partial agonist, α₂-adrenergic receptor antagonist, and D₂ autoreceptor antagonist,^[1] and testosterone, an androgen or androgen receptor agonist, which is under development by the pharmaceutical company Emotional Brain for the treatment of female sexual dysfunction.^{[2] [3]} Both buspirone and testosterone have individually been found to be effective in the treatment of female sexual dysfunction in clinical studies, and so their combination could be anticipated to be even more effective.^{[4] [5] [6]} As of January 2016, the combination is in phase II clinical trials, with a phase III trial being planned in the United States and Europe.

See also

• List of investigational sexual dysfunction drugs
• Bremelanotide
• Flibanserin
• Intrinsa

External links

• Buspirone/testosterone - AdisInsight
• Female sexual disorders: Treatment options in the pipeline

Notes and References

1. Loane C, Politis M . Buspirone: what is it all about? . Brain Research . 1461 . 111–118 . June 2012 . 22608068 . 10.1016/j.brainres.2012.04.032 . 11734819 .
2. Web site: Buspirone/Testosterone - Emotional Brain . AdisInsight . Springer Nature Switzerland AG .
3. Book: Meston CM, Stanton AM . Treatment of Female Sexual Interest/Arousal Disorder . IsHak WW . The Textbook of Clinical Sexual Medicine . 2017. 165–168. 10.1007/978-3-319-52539-6_11. 978-3-319-52538-9.
4. Goldstein I, Kim NN, Clayton AH, DeRogatis LR, Giraldi A, Parish SJ, Pfaus J, Simon JA, Kingsberg SA, Meston C, Stahl SM, Wallen K, Worsley R . 6 . Hypoactive Sexual Desire Disorder: International Society for the Study of Women's Sexual Health (ISSWSH) Expert Consensus Panel Review . Mayo Clinic Proceedings . 92 . 1 . 114–128 . January 2017 . 27916394 . 10.1016/j.mayocp.2016.09.018 . free .
5. Nappi RE, Cucinella L . Advances in pharmacotherapy for treating female sexual dysfunction . Expert Opinion on Pharmacotherapy . 16 . 6 . 875–887 . April 2015 . 25732267 . 10.1517/14656566.2015.1020791 . 24678911 .
6. Bolour SY, Braunstein GD . Pharmacologic treatment options for hypoactive sexual desire disorder . Women's Health . 1 . 2 . 263–277 . September 2005 . 19803843 . 10.2217/17455057.1.2.263 . free .