Bunitrolol Explained

Bunitrolol is a beta-adrenergic antagonist.[1]

Synthesis

2-Hydroxybenzonitrile (1) is treated with epichlorohydrin and sodium hydroxide to give the epoxide (2). Addition of tert-butylamine completes the synthesis of bunitrolol.[2]

See also

Notes and References

  1. 20310018. 2010. Haddad. S. Poulin. P. Funk. C. Extrapolating in vitro metabolic interactions to isolated perfused liver: Predictions of metabolic interactions between R-bufuralol, bunitrolol, and debrisoquine. 99. 10. 4406–26. 10.1002/jps.22136. Journal of Pharmaceutical Sciences.
  2. Herbert Koppe, Albrecht Engelhardt, Karl Zeile, (1976 to Boehringer Ingelheim Gmbh).

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