Bufuralol Explained

Bufuralol is a potent beta-adrenoceptor antagonist with partial agonist activity.^[1] It is metabolized by CYP2D6.^[2]

Most beta blockers are aryloxypropanolamine-based. In this rare exception, the benzofuran oxygen is part of a ring instead of derived from the epichlorohydrin precursor.

Notes and References

1. 2878678 . 1986 . Pringle . TH . Francis . RJ . East . PB . Shanks . RG . Pharmacodynamic and pharmacokinetic studies on bufuralol in man . 22 . 5 . 527–34 . 1401192 . British Journal of Clinical Pharmacology . 10.1111/j.1365-2125.1986.tb02931.x.
2. Web site: Flockhart DA . Drug Interactions: Cytochrome P₄₅₀ Drug Interaction Table . . 2007 . Retrieved on July 2011