Bufotenidine Explained

Bufotenidine, also known as 5-hydroxy-N,N,N-trimethyltryptammonium (5-HTQ), is a toxin related to bufotenin, serotonin, and other tryptamines which is found in the venom of a variety of toads.^{[1] [2]} It acts as a selective 5-HT₃ receptor agonist, and has been used in scientific research to study the function of the 5-HT₃ receptor, though this use has been limited by the fact that, as a quaternary amine, it is unable to readily cross the blood-brain-barrier.^[3]

See also

• 2-Methyl-5-HT
• Chlorophenylbiguanide

Notes and References

1. Wieland, Heinrich . Konz, Wilhelm . Mittasch, Heinz . Toad poisons. VII. Constitution of bufotenin and bufotenidine . Justus Liebigs Annalen der Chemie . 1934 . 513 . 1–25 . 10.1002/jlac.19345130102.
2. Raymond-Hamet . Bufotenidine, an extremely active principle of the venom of the common toad (Bufo bufo) . Comptes rendus des séances de la Société de biologie et de ses filiales . 1943 . 137 . 74–75.
3. Book: Bryan L. Roth. The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics. 17 August 2008. Springer Science & Business Media. 978-1-59745-080-5. 108–.