Brunfelsamidine Explained

Brunfelsamidine is a poisonous pyrrolidine occurring in several species belonging to the Solanaceous (nightshade family) genus Brunfelsia, which has convulsant and neurotoxic effects.^[1] It is a fairly common cause of poisoning among domestic animals such as cows and dogs that eat the plant. Symptoms are similar to poisoning from strychnine and can last from a few hours up to several days.^[2] It is also a weak tryptase (type of serine protease) inhibitor^[3] and found in Leptonychia pubescens

Notes and References

1. Lloyd HA. et al . Brunfelsamidine: a novel convulsant from the medicinal plant Brunfelsia grandiflora . . 1985 . 26 . 22 . 2623–4 . 10.1016/S0040-4039(00)98119-X.
2. Book: Bonagura JD, Twedt DC . Kirk's Current Veterinary Therapy XIV . 978-0-7216-9497-9.
3. Yang LK, Ng SP, Flotow H, Yoganathan K, Daramola BO, Soejarto DD, Buss AD, Butler MS . Pyrrole carboxamidine tryptase inhibitors from Leptonychia pubescens . . 71 . 11 . 1071–2 . November 2005 . 16320213 . 10.1055/s-2005-873111 .