Bruceantin Explained

Bruceantin is a chemical compound that was first isolated from the plant Brucea antidysenterica in 1973.^[1] Chemically, it is classified as a secotriterpenoid and a quassinoid.

Bucreantin has attracted interest as a potential antitumor drug because of its antineoplastic activity.^[2] It inhibits the peptidyl transferase elongation reaction, resulting in decreased protein and DNA synthesis.^[2] Bruceantin also has antibiotic, antiamoebic,^[3] and antimalarial activity.^[2]

Phase I and II clinical trials were conducted for the treatment of metastatic breast cancer and malignant melanoma, but tumor regression was not observed and clinical development was terminated.^{[4] [5]}

Notes and References

1. Bruceantin, a new potent antileukemic simaroubolide from Brucea antidysenterica . S. Morris Kupchan, Ronald W. Britton, Myra F. Ziegler, and Carl W. Sigel . J. Org. Chem. . 1973 . 38 . 1 . 178–179 . 10.1021/jo00941a049 . 4682660 .
2. Web site: Bruceantin . NCI Cancer Dictionary . National Institutes of Health .
3. Antimicrobial Agents and Chemotherapy . 22 . 2 . Bruceantin, a potent amoebicide from a plant, Brucea antidysenterica . 2021 . F D Gillin, D S Reiner, M Suffness . 342–345 . 10.1128/AAC.22.2.342 . 6100431 . 183739 .
4. J Nat Prod . 2004 . 67 . 2 . 269–272 . 10.1021/np030304+ . Antitumor activity of bruceantin: an old drug with new promise . Muriel Cuendet, John M Pezzuto . 14987068 .
5. Web site: Bruceantin . Inxsight Drugs .