Bromoderma Explained

Bromoderma
Synonyms:	Bromoderma tuberosum
Field:	Dermatology

Bromoderma is a skin condition characterized by an eruption of papules and pustules on the skin.^[1] It is caused by hypersensitivity to bromides, such as those found in certain drugs. There is at least one reported case of bromoderma caused by excessive consumption of a soft drink (Ruby Red Squirt) containing brominated vegetable oil.^[2]

Signs and symptoms

The disease's symptoms can range from a mild acneiform rash with papules and pustules to more severe conditions like panniculitis, ulcers, and vegetative nodules, also referred to as tuberous or vegetating bromoderma. Lesions usually affect the lower limbs, scalp, and face.^{[3] [4]}

Causes

One could characterize bromoderma as a kind of delayed hypersensitivity reaction, even though its pathogenesis is still unknown.^[5] Lesions can develop as soon as eight days after the medicine is first administered, but they typically do so after a prolonged period of use. High sebaceous gland concentrations on the skin are typically the site of lesions.^[6]

Diagnosis

Skin lesions, a patient's history of using bromide, and the healing of lesions following drug withdrawal can all be used to make a diagnosis.^[7]

See also

• Skin lesion
• List of cutaneous conditions

Further reading

• Paloni . Giulia . Mattei . Ilaria . Ravagnan . Enrico . Cutrone . Mario . Infantile Bromoderma . The Journal of Pediatrics . Elsevier BV . 163 . 3 . 2013 . 0022-3476 . 10.1016/j.jpeds.2013.03.071 . 920–920.e1 . 23651770 . none.

Notes and References

1. Book: James WD, Berger T, Elston D . Andrews' Diseases of the Skin: Clinical Dermatology . 2006 . Saunders Elsevier . Philadelphia . 978-0-7216-2921-6 . 10th.
2. Jih DM, Khanna V, Somach SC . Bromoderma after excessive ingestion of Ruby Red Squirt . The New England Journal of Medicine . 348 . 19 . 1932–1934 . May 2003 . 12736294 . 10.1056/NEJM200305083481921 . free .
3. Nabatame . Shin . Saito . Yoshiaki . Sakuma . Hiroshi . Komaki . Hirofumi . Nakagawa . Eiji . Sugai . Kenji . Sasaki . Masayuki . Uchiyama . Kentaro . Kosaka . Maki . Bromoderma in a patient with migrating partial seizures in infancy . Epilepsy Research . Elsevier BV . 91 . 2–3 . 2010 . 0920-1211 . 10.1016/j.eplepsyres.2010.07.008 . 283–288. 20674275 . 3408441 .
4. Anzai . Saburo . Fujiwara . Sakuhei . Inuzuka . Miki . Bromoderma . International Journal of Dermatology . Wiley . 42 . 5 . 2003 . 0011-9059 . 10.1046/j.1365-4362.2003.01734.x . 370–371. 12755974 . 221812784 .
5. Maffeis . Laura . Musolino . Maria Carmela . Cambiaghi . Stefano . Single-plaque vegetating bromoderma . Journal of the American Academy of Dermatology . Elsevier BV . 58 . 4 . 2008 . 0190-9622 . 10.1016/j.jaad.2007.08.011 . 682–684. 18342716 .
6. Hoefel . Isadora da Rosa . Camozzato . Fernanda Oliveira . Hagemann . Laura Netto . Rhoden . Deise Louise Bohn . Kiszewski . Ana Elisa . Bromoderma in an infant . Anais Brasileiros de Dermatologia . FapUNIFESP (SciELO) . 91 . 5 suppl 1 . 2016 . 0365-0596 . 10.1590/abd1806-4841.20165013 . 17–19. 28300882 . 5324981 .
7. Bel . Susana . Bartralot . Ramón . García . Daniel . Aparicio . Gloria . Castells . Antonio . Vegetant Bromoderma in an Infant . Pediatric Dermatology . Wiley . 18 . 4 . 2001 . 0736-8046 . 10.1046/j.1525-1470.2001.01954.x . 336–338. 11576411 . 19631925 .