Bromadoline Explained

Bromadoline (U-47931E)[1] is an opioid analgesic selective for the μ-opioid receptor[2] developed by the Upjohn company in the 1970s.[3] The drug has a potency lying between that of codeine and morphine, being slightly stronger than pentazocine.[4] Bromadoline is related to AH-7921 and U-47700.[5]

See also

Notes and References

  1. Book: Unlisted Drugs . 34–35 . 392 . 1982 . Pharmaceutical Section, Special Libraries Association . Chatham . 978-0-913210-13-0 .
  2. Hayes AG, Skingle M, Tyers MB . Evaluation of the receptor selectivities of opioid drugs by investigating the block of their effect on urine output by beta-funaltrexamine . The Journal of Pharmacology and Experimental Therapeutics . 240 . 3 . 984–8 . March 1987 . 3559988 .
  3. Web site: Patent US4098904 - Analgesic N-(2-aminocycloaliphatic)benzamides . 4 July 1978 . Jacob Szmuszkovicz . The Upjohn Company.
  4. Hayes AG, Sheehan MJ, Tyers MB . Differential sensitivity of models of antinociception in the rat, mouse and guinea-pig to mu- and kappa-opioid receptor agonists . British Journal of Pharmacology . 91 . 4 . 823–32 . August 1987 . 2822190 . 1853585 . 10.1111/j.1476-5381.1987.tb11281.x .
  5. Cheney BV, Szmuszkovicz J, Lahti RA, Zichi DA . Factors affecting binding of trans-N-[2-(methylamino)cyclohexyl]benzamides at the primary morphine receptor . Journal of Medicinal Chemistry . 28 . 12 . 1853–64 . December 1985 . 2999404 . 10.1021/jm00150a017 .

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