| Brienne | |
| Commune Status: | Commune |
| Image Coat Of Arms: | Blason Brienne (Saône-et-Loire).svg |
| Insee: | 71061 |
| Postal Code: | 71290 |
| Arrondissement: | Louhans |
| Canton: | Cuiseaux |
| Coordinates: | 46.5578°N 5.0225°W |
| Elevation M: | 187 |
| Elevation Min M: | 172 |
| Elevation Max M: | 199 |
| Area Km2: | 5.65 |
Brienne is a commune in the Saône-et-Loire department in the region of Bourgogne-Franche-Comté in eastern France. It is 37 km from Mâcon, the department capital.
The Sâne Vive forms the commune's south-eastern border, then flow into the Seille, which forms its western and north-western borders.