Brian S. Kim Explained

Brian S. Kim
Birth Place:New York, NY
Education:Haverford College, University of Washington School of Medicine, University of Pennsylvania School of Medicine
Occupation:Sol and Clara Kest Professor, Vice Chair of Research, Site Chair, Director of Mark Lebwohl Center
Website:Kim Lab
Field:Dermatology, Allergy, Immunology, Neuroimmunology, Sensory Biology
Work Institutions:Mount Sinai Health System

Brian S. Kim is the Sol and Clara Kest Professor, Vice Chair of Research, and Site Chair of Mount Sinai West and Morningside in the Kimberly and Eric J. Waldman Department of Dermatology at Icahn School of Medicine at Mount Sinai.[1] [2] [3] He is also Director of the Mark Lebwohl Center for Neuroinflammation and Sensation.[4]

Education

Kim received his B.S. in chemistry with honors from Haverford College in 2001 and his M.D. from the University of Washington in 2007. He was a Howard Hughes Medical Institute-National Institutes of Health Research Scholar under Stephen I. Katz, and completed his residency in dermatology at the Perelman School of Medicine at the University of Pennsylvania.[5] [6] He completed a postdoctoral fellowship under David Artis,[7] leading to a Master of Translational Research.

Research

He was the first to identify IL-4 receptor signaling on sensory neurons,[8] which critically informed new therapies like dupilumab.[9] Kim's group also was the first lab to identify JAK1 signaling in sensory neurons,[10] building on previous research which showed a significant reduction of itch symptoms in response to treatment with JAK inhibitors.[11] [12] While these previous works investigated JAK inhibition as an anti-inflammatory treatment, Kim and colleagues found that disruption of neuronal JAK1 signaling limits both inflammatory and non-inflammatory itch, suggesting that JAK inhibitors may represent a novel neuromodulatory approach to target itch in atopic dermatitis[13] Kim also designed the pivotal phase 2 clinical trial that ultimately led to the approval of topical ruxolitinib for atopic dermatitis.[14]

Notes and References

  1. Web site: Brian S. Kim - Dermatology Mount Sinai - New York . August 29, 2022 . Mount Sinai Health System . en.
  2. Web site: Brian S. Kim . August 29, 2022 . Brian Kim Lab . en-US.
  3. Web site: Brian S. Kim Icahn School of Medicine . August 29, 2022 . Icahn School of Medicine at Mount Sinai . en-US.
  4. Web site: Top Researcher of Itch and Inflammatory Skin Conditions to Join Mount Sinai's Department of Dermatology Mount Sinai - New York . August 29, 2022 . Mount Sinai Health System . en-US.
  5. Web site: Dr. Brian Kim, MD – New York, NY Dermatology on Doximity . August 29, 2022 . Doximity . en.
  6. Web site: ORCID . August 29, 2022 . orcid.org.
  7. Web site: T32 Past Trainees . August 29, 2022 . Penn Dermatology Training . en-US.
  8. Oetjen . LK . Mack . MR . Feng . J . Whelan . TM . Niu . H . Guo . CJ . Chen . S . Trier . AM . Xu . AZ . Tripathi . SV . Luo . J . Gao . X . Yang . L . Hamilton . SL . Wang . PL . Brestoff . JR . Council . ML . Brasington . R . Schaffer . A . Brombacher . F . Hsieh . CS . Gereau RW . 4th . Miller . MJ . Chen . ZF . Hu . H . Davidson . S . Liu . Q . Kim . BS . Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch. . Cell . September 21, 2017 . 171 . 1 . 217–228.e13 . 10.1016/j.cell.2017.08.006 . 28890086. 5658016 .
  9. Guttman-Yassky . E . Emma Guttman-Yassky . Bissonnette . R . Ungar . B . Suárez-Fariñas . M . Ardeleanu . M . Esaki . H . Suprun . M . Estrada . Y . Xu . H . Peng . X . Silverberg . JI . Menter . A . Krueger . JG . Zhang . R . Chaudhry . U . January 2019 . Dupilumab progressively improves systemic and cutaneous abnormalities in patients with atopic dermatitis. . The Journal of Allergy and Clinical Immunology . 143 . 1 . 155–172 . 10.1016/j.jaci.2018.08.022 . 30194992 . 52177141 . free . Swanson . B . Graham . NMH . Pirozzi . G . Yancopoulos . GD . D Hamilton . JD.
  10. Oetjen . LK . Mack . MR . Feng . J . Whelan . TM . Niu . H . Guo . CJ . Chen . S . Trier . AM . Xu . AZ . Tripathi . SV . Luo . J . Gao . X . Yang . L . Hamilton . SL . Wang . PL . Brestoff . JR . Council . ML . Brasington . R . Schaffer . A . Brombacher . F . Hsieh . CS . Gereau RW . 4th . Miller . MJ . Chen . ZF . Hu . H . Davidson . S . Liu . Q . Kim . BS . Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch. . Cell . September 21, 2017 . 171 . 1 . 217–228.e13 . 10.1016/j.cell.2017.08.006 . 28890086. 5658016 .
  11. Levy . LL . Urban . J . King . BA . Treatment of recalcitrant atopic dermatitis with the oral Janus kinase inhibitor tofacitinib citrate. . Journal of the American Academy of Dermatology . September 2015 . 73 . 3 . 395–9 . 10.1016/j.jaad.2015.06.045 . 26194706. free .
  12. Bissonnette . R . Papp . KA . Poulin . Y . Gooderham . M . Raman . M . Mallbris . L . Wang . C . Purohit . V . Mamolo . C . Papacharalambous . J . Ports . WC . Topical tofacitinib for atopic dermatitis: a phase IIa randomized trial. . The British Journal of Dermatology . November 2016 . 175 . 5 . 902–911 . 10.1111/bjd.14871 . 27423107. 3581619 . free .
  13. Oetjen . LK . Mack . MR . Feng . J . Whelan . TM . Niu . H . Guo . CJ . Chen . S . Trier . AM . Xu . AZ . Tripathi . SV . Luo . J . Gao . X . Yang . L . Hamilton . SL . Wang . PL . Brestoff . JR . Council . ML . Brasington . R . Schaffer . A . Brombacher . F . Hsieh . CS . Gereau RW . 4th . Miller . MJ . Chen . ZF . Hu . H . Davidson . S . Liu . Q . Kim . BS . Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch. . Cell . September 21, 2017 . 171 . 1 . 217–228.e13 . 10.1016/j.cell.2017.08.006 . 28890086. 5658016 .
  14. Kim . BS . Howell . MD . Kang . S . Nasir . A . Kuligowski . ME. Treatment of atopic dermatitis with ruxolitinib cream (JAK1/2 inhibitor) or triamcinolone cream. . Journal of Allergy and Clinical Immunology . February 2020 . 145. 2 . 572–582 . 10.1016/j.jaci.2019.08.042 . 31629805. 204812790 . free .

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