Bremazocine Explained

Bremazocine is a κ-opioid receptor agonist related to pentazocine. It has potent and long-lasting analgesic and diuretic effects.[1] It has 200 times the activity of morphine, but appears to have no addictive properties and does not depress breathing.[2] The crystal structure of bremazocine was determined in 1984 [3]

See also

Notes and References

  1. Dortch-Carnes J, Potter DE . Bremazocine: a kappa-opioid agonist with potent analgesic and other pharmacologic properties . CNS Drug Reviews . 11 . 2 . 195–212 . 2005 . 16007240 . 10.1111/j.1527-3458.2005.tb00270.x. 6741727 .
  2. Book: Patrick, Graham . An Introduction to Medicinal Chemistry . 5th expanded . 641 . Oxford University Press . 2013 . 978-0199697397 .
  3. Verlinde CL, Blaton NM, De Ranter CJ, Peeters OM . 5-Ethyl-2'-hydroxy-2-[(1-hydroxycyclopropyl) methyl]-9, 9-dimethyl-6, 7-benzomorphan hydrochloride (bremazocine), C20H29NO2. HCl . Acta Crystallogr. C. 40 . 1759–1761. 1984. 10 . 10.1107/S0108270184009434 . 1984AcCrC..40.1759V .

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