| Brandywine | |
| Settlement Type: | Census-designated place (CDP) |
| Pushpin Map: | West Virginia |
| Pushpin Map Caption: | Location of Brandywine in West Virginia |
| Subdivision Type: | Country |
| Subdivision Name: | United States |
| Subdivision Type1: | State |
| Subdivision Name1: | West Virginia |
| Subdivision Type2: | County |
| Subdivision Name2: | Pendleton |
| Area Footnotes: | [1] |
| Area Total Sq Mi: | 0.491 |
| Area Land Sq Mi: | 0.491 |
| Area Water Sq Mi: | 0 |
| Population As Of: | 2019 |
| Population Footnotes: | [2] |
| Population Total: | 147 |
| Population Density Sq Mi: | auto |
| Timezone: | Eastern (EST) |
| Utc Offset: | -5 |
| Timezone Dst: | EDT |
| Utc Offset Dst: | -4 |
| Coordinates: | 38.6219°N -79.2414°W |
| Postal Code Type: | ZIP codes |
| Blank Name: | FIPS code |
| Blank1 Name: | GNIS feature ID |
| Blank1 Info: | 2586770 |
Brandywine is a census-designated place (CDP) located on U.S. Highway 33 in Pendleton County, West Virginia, United States. The town lies along the South Fork South Branch Potomac River at its confluence with Hawes Run. At the 2019 United States census, its population was 147.
Located nearby within the George Washington National Forest is the Brandywine Recreation Area which includes Brandywine Lake, a reservoir on Hawes Run created by the South Fork Structure Number 13 Dam.
Located near Brandywine is the Old Probst Church, listed on the National Register of Historic Places in 1986.