Bouvardin Explained

Bouvardin is a bicyclic hexapeptide isolated from Bouvardia ternifolia. Its chemical formula is C40H48N6O10. It is derived from the amino acid sequence Ala-Ala-Tyr-Ala-Tyr-Tyr. It has demonstrated certain anti-cancerous activities by inhibiting protein synthesis through inhibition of 80S ribosomes (eukaryotic ribosomes).[1]

Notes and References

  1. 10.1021/ja00098a015. Total Synthesis of Bouvardin, O-Methylbouvardin, and O-Methyl-N9-desmethylbouvardin. Journal of the American Chemical Society. 116. 19. 8544–8556. 1994. Boger. Dale L. Patane. Michael A. Zhou. Jiacheng.

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