Bothrolysin Explained

Bothrolysin
Ec Number:	3.4.24.50
Cas Number:	443890-65-1

Bothrolysin (Bothrops metalloendopeptidase J, J protease) is an enzyme.^[1] This enzyme catalyses the following chemical reaction

Cleavage of Gln⁴-His, Ser⁹-His and Ala¹⁴-Leu of insulin B chain and Pro-Phe of angiotensin I

This endopeptidase is present in the venom of the jararaca snake (Bothrops jararaca).

Notes and References

1. Tanizaki MM, Zingali RB, Kawazaki H, Imajoh S, Yamazaki S, Suzuki K . Purification and some characteristics of a zinc metalloprotease from the venom of Bothrops jararaca (jararaca) . Toxicon . 27 . 7 . 747–55 . 1989 . 2781574 . 10.1016/0041-0101(89)90041-x .