Bornaprolol Explained

Bornaprolol is a beta-adrenergic antagonist.[1]

Synthesis

The reaction between 2-(Bicyclo[2.2.1]hept-2-yl)phenol [17152-43-1] (1) and epichlorohydrin [106-89-8] (2) in the presence of sodium metal gives (3). Opening of the oxirane by treatment with isopropylamine [75-31-0] (4) completed the synthesis of Bornaprolol (5).

Notes and References

  1. 2442536. 1987. Cheymol. G. Jaillon. P. Lecoq. B. Lecoq. V. Cheymol. A. Krumenacker. M. Cardiovascular beta-adrenergic blocking effects of bornaprolol in humans: Relation to dose and plasma concentration. 9. 6. 694–8. Journal of Cardiovascular Pharmacology. 10.1097/00005344-198706000-00009. 38782602. free.

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