Bone morphogenetic protein receptor explained

Bone morphogenetic protein receptors are serine-threonine kinase receptors. Transforming growth factor beta family proteins bind to these receptors.^[1] There are four bone morphogenetic protein receptors:^[2]

• Bone morphogenetic protein receptor, type 1:
  • ACVR1
  • BMPR1A
  • BMPR1B
• Bone morphogenetic protein receptor, type 2

Structure

Both type 1 and 2 bone morphogenetic protein receptors have a single transmembrane segment. Additionally, both types have a cysteine-rich extracellular domain and a cytoplasmic serine threonine kinase domain.^[3] Type 1 contains a glycine-serine-rich domain to be phosphorylated by type 2 kinase domain, initiating the signaling transduction pathway of the SMAD signaling cascade. The wrist epitope motif on BMP-2 has a high-affinity binding site for BMPR-IA. The knuckle epitope motif on BMP-2 has a low-affinity binding site for BMPR-II.^[4]

See also

• Bone morphogenetic protein

Notes and References

1. Miyazono K, Kamiya Y, Morikawa M . Bone morphogenetic protein receptors and signal transduction . Journal of Biochemistry . 147 . 1 . 35–51 . January 2010 . 19762341 . 10.1093/jb/mvp148 . free .
2. Pasche B . December 2008 . The TGF Family. Cold Spring Harbor Monograph Series, Volume 50. Edited by Rik Derynck, Kohei Miyazono. Cold Spring Harbor (New York): Cold Spring Harbor Laboratory Press. xiv-1114 p.; ill.; index. 9780879697525. 2008. . The Quarterly Review of Biology . 83 . 4 . 405–405 . 10.1086/596254 .
3. Mace PD, Cutfield JF, Cutfield SM . High resolution structures of the bone morphogenetic protein type II receptor in two crystal forms: implications for ligand binding . Biochemical and Biophysical Research Communications . 351 . 4 . 831–8 . December 2006 . 17094948 . 10.1016/j.bbrc.2006.10.109 .
4. Book: Miyazono K, Shimanuki T . Chapter 55: Bone morphogenetic protein receptors and actions. . Bilezikian JP, Raisz LG, Martin TJ . Principles of bone biology . Third . January 2008 . 1177–1196 . San Diego . Academic Press . 978-0-12-373884-4 . 10.1016/B978-0-12-373884-4.00069-0 .